Yoshida M, Ueda S, Machida J, Ikegami K
J Urol. 1987 May;137(5):1048-52. doi: 10.1016/s0022-5347(17)44357-6.
The change of the response to angiotensin II (AII) and norepinephrine (NE) was evaluated in vivo and vitro in the chronic phase of two-kidney, one-clip renovascular hypertensive rabbits. In the constricted group, systemic blood pressure (BP) was significantly higher and plasma renin activity (PRA) was significantly lower than in the control group. Subpressor doses of AII and NE injections in the constricted group produced significant elevations of BP. In the aortic, renal and iliac arterial strips, the reactivity to AII (10(-10) to 10(-8) M) and NE (10(-10) to 10(-7) M) was significantly increased in the constricted group as compared to the control group. In the constricted group, sodium loading produced BP elevation with decreased PRA and shifted the dose-response curves by AII and NE to the left, whereas sodium restriction decreased BP and shifted the curves to the right. In the control group, altered sodium intake did not affect BP but affected only the dose-response curves by AII. These results suggested that in the chronic phase of renovascular hypertensive rabbits, the increased reactivity to AII and NE may contribute to the maintenance of hypertension.
在双肾单夹肾血管性高血压兔的慢性期，对血管紧张素II（AII）和去甲肾上腺素（NE）的反应变化进行了体内和体外评估。在狭窄组中，全身血压（BP）显著高于对照组，血浆肾素活性（PRA）显著低于对照组。在狭窄组中，注射低于升压剂量的AII和NE可使血压显著升高。与对照组相比，在主动脉、肾动脉和髂动脉条带中，狭窄组对AII（10^(-10)至10^(-8) M）和NE（10^(-10)至10^(-7) M）的反应性显著增加。在狭窄组中，钠负荷导致血压升高，PRA降低，并使AII和NE的剂量反应曲线向左移动，而钠限制则降低血压并使曲线向右移动。在对照组中，钠摄入量的改变不影响血压，但仅影响AII的剂量反应曲线。这些结果表明，在肾血管性高血压兔的慢性期，对AII和NE反应性的增加可能有助于维持高血压。
