高血压及冠心病患者血清单核细胞趋化蛋白-1 和 Lp-PLA2 的变化及意义。

Changes and significance of serum monocyte chemoattractant protein-1 and Lp-PLA2 in patients with hypertension and coronary heart disease.

机构信息

Department of Cardiovascular Medicine, Baoji Hospital of Traditional Chinese Medicine, China.

Department of Cardiovascular Medicine, Xijing Hospital, Air Force Medical University, China.

出版信息

J Pak Med Assoc. 2022 Jun;72(6):1114-1117. doi: 10.47391/JPMA.3244.

DOI:10.47391/JPMA.3244

PMID:35751319

Abstract

OBJECTIVE

To explore the combined application value of serum monocyte chemoattractant protein-1 and lipoprotein-associated phospholipase A2 in the diagnosis of hypertension and coronary heart disease.

METHODS

The cross-sectional case-control study was conducted at Baoji Hospital of Traditional Chinese medicine, Shaanxi, China, from April 2018 to May 2020, and comprised patients with suspected hypertension and coronary heart disease. Patients with both hypertension and coronary heart disease formed Group A, and those with simple hypertension formed Group B. Healthy individuals formed the control Group C. Receiver operating characteristic curve was used to evaluate the value of serum monocyte chemoattractant protein-1 combined with lipoprotein-associated phospholipase A2 in the diagnosis of hypertension complicated with coronary heart disease. Data was analysed using SPSS 25.

RESULTS

Of the 306 subjects, there were 122(40%) in Group A; 68(55.7%) males and 54(44.3%) females with mean age 68.77±5.76 years. There were 92(30%) cases in Group B; 51(55.4%) males and 41(44.6%) females with mean age 68.80±5.28 years. Group C had 92(30%) cases; 50(54.3%) males and 42(45.7%) females with mean age 67.85±5.29 years. Serum monocyte chemoattractant protein-1 and lipoprotein-associated phospholipase A2 levels were higher in Group A than the other two groups (p<0.001), and the levels in patients with carotid plaque total score <2 were lower than those with carotid plaque total score >2 (p<0.001). Area under receiver operating characteristic curve of the combination of the serum markers was 0.883 (95% confidence interval: 0.837-0.929, p<0.001), which was greater than that of two serum markers alone (p<0.05).

CONCLUSIONS

Monocyte chemoattractant protein-1 and lipoprotein-associated phospholipase A2 may be involved in pathogenesis of elevated blood pressure and coronary artery disease. Combined detection of the two serum markers can provide a certain basis for the diagnosis and treatment of hypertension and coronary heart disease.

摘要

目的

探讨血清单核细胞趋化蛋白-1（MCP-1）与脂蛋白相关磷脂酶 A2（Lp-PLA2）联合应用对高血压及冠心病的诊断价值。

方法

采用病例对照研究方法，于 2018 年 4 月至 2020 年 5 月在陕西省宝鸡市中医医院收集疑似高血压及冠心病患者，同时患有高血压和冠心病者为 A 组，单纯高血压患者为 B 组，健康体检者为 C 组。采用受试者工作特征曲线（ROC 曲线）评价血清 MCP-1 联合 Lp-PLA2 对高血压合并冠心病的诊断价值。采用 SPSS 25 软件进行数据统计分析。

结果

最终共纳入 306 例患者，A 组 122 例（40%），男 68 例（55.7%），女 54 例（44.3%），年龄 68.77±5.76 岁；B 组 92 例（30%），男 51 例（55.4%），女 41 例（44.6%），年龄 68.80±5.28 岁；C 组 92 例（30%），男 50 例（54.3%），女 42 例（45.7%），年龄 67.85±5.29 岁。A 组血清 MCP-1 与 Lp-PLA2 水平高于 B 组和 C 组（P<0.001），颈动脉斑块总积分<2 分者低于颈动脉斑块总积分>2 分者（P<0.001）。血清标志物联合检测的 ROC 曲线下面积为 0.883（95%CI：0.837~0.929，P<0.001），大于两项血清标志物单独检测（P<0.05）。