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经皮/小切口腹腔镜胎儿镜治疗开放性脊柱裂:一种新的手术技术。

Percutaneous/mini-laparotomy fetoscopic repair of open spina bifida: a novel surgical technique.

机构信息

Department of Obstetrics and Gynecology, Los Angeles Fetal Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA; The USFetus Research Consortium, Miami, FL.

Department of Obstetrics and Gynecology, Los Angeles Fetal Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Intermountain Healthcare, Salt Lake City, UT; Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Utah Health, Salt Lake City, UT.

出版信息

Am J Obstet Gynecol. 2022 Sep;227(3):375-383. doi: 10.1016/j.ajog.2022.05.032. Epub 2022 Jun 23.

Abstract

Open spina bifida is the most common congenital anomaly of the central nervous system compatible with life. Prenatal repair of open spina bifida via open maternal-fetal surgery has been shown to improve postnatal neurologic outcomes, including reducing the need for ventriculoperitoneal shunting and improving lower neuromotor function. Fetoscopic repair of open spina bifida minimizes the maternal risks while providing similar neurosurgical outcomes to the fetus. The following 2 fetoscopic techniques are currently in use: (1) the laparotomy-assisted approach, and (2) the percutaneous approach. The laparotomy-assisted fetoscopic technique appears to be associated with a lesser risk of preterm birth than the percutaneous approach. However, the percutaneous approach avoids laparotomy and uterine exteriorization and is associated with lesser anesthesia risk and improved maternal postsurgical recovery. The purpose of this article was to describe our experience with a modified surgical approach, which we call percutaneous/mini-laparotomy fetoscopy, in which access to the uterus for one of the ports is done via a mini-laparotomy, whereas the other ports are inserted percutaneously. This technique draws on the benefits of both the laparotomy-assisted and the percutaneous techniques while minimizing their drawbacks. This surgical approach may prove invaluable in the prenatal repair of open spina bifida and other complex fetal surgical procedures.

摘要

开放性脊柱裂是最常见的与生命兼容的中枢神经系统先天性异常。通过开放式母胎手术对开放性脊柱裂进行产前修复已被证明可以改善产后神经功能结局,包括减少脑室-腹腔分流术的需求和改善下运动神经功能。经阴道修复开放性脊柱裂最大限度地降低了母亲的风险,同时为胎儿提供了类似的神经外科手术结果。目前有以下 2 种经阴道修复技术:(1)剖腹辅助方法,和(2)经皮方法。与经皮方法相比,剖腹辅助经阴道修复技术似乎与早产风险较低相关。然而,经皮方法避免了剖腹手术和子宫外置,与麻醉风险较低和改善母亲术后恢复相关。本文的目的是描述我们使用改良手术方法的经验,我们称之为经皮/迷你剖腹经阴道镜检查,其中一个端口进入子宫的通道通过迷你剖腹手术完成,而其他端口则经皮插入。这种技术结合了剖腹辅助和经皮技术的优点,同时最大限度地减少了它们的缺点。这种手术方法可能在开放性脊柱裂和其他复杂胎儿手术的产前修复中非常有价值。

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