State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610000, China.
Cell Signal. 2022 Sep;97:110394. doi: 10.1016/j.cellsig.2022.110394. Epub 2022 Jun 24.
Osteoporosis is a widespread disease characterized by bone mass loss and microarchitectural deterioration. The side effects of clinical drugs make mesenchymal stem cells (MSCs)-based therapy gain increasing focus in the treatment of osteoporosis. MSCs need to migrate to the site of damage and undergo differentiation in order to participate in the subsequent bone repair process. Therefore, the homing ability of MSCs may be related to the repair ability. Here, we proposed a novel method to screen MSCs with high migration capacity and confirmed that these MSCs exhibited higher osteogenic differentiation ability both in vivo and in vitro. Further results indicated that MSCs with high migration ability could partly rescue the bone loss of ovarectomized (OVX) rats. Higher expression of Platelet-derived growth factors receptor β- (PDGFRβ) and more nuclear transduction of β-catenin in MSCs with high migration ability may be responsible for biological functions. This article may provide a method to improve the efficacy of MSCs-based therapy in the clinic.
骨质疏松症是一种广泛存在的疾病，其特征是骨量流失和微观结构恶化。临床药物的副作用使得基于间充质干细胞（MSCs）的治疗在治疗骨质疏松症方面受到越来越多的关注。MSCs 需要迁移到损伤部位，并进行分化，以便参与随后的骨修复过程。因此，MSCs 的归巢能力可能与修复能力有关。在这里，我们提出了一种新的方法来筛选具有高迁移能力的 MSCs，并证实这些 MSCs 在体内和体外均表现出更高的成骨分化能力。进一步的结果表明，具有高迁移能力的 MSCs 可以部分挽救去卵巢（OVX）大鼠的骨丢失。在具有高迁移能力的 MSCs 中，血小板衍生生长因子受体β-（PDGFRβ）的高表达和β-catenin 的更多核转位可能是其生物学功能的原因。本文可能为提高临床中基于 MSCs 的治疗效果提供了一种方法。
Eur Rev Med Pharmacol Sci. 2019-9
MedComm (2020). 2023-5-11
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