Smith G P, Bourbonais K A, Jerome C, Simansky K J
Pharmacol Biochem Behav. 1987 Mar;26(3):585-91. doi: 10.1016/0091-3057(87)90170-5.
Recent pharmacological experiments suggested that central dopaminergic (DA) mechanisms are necessary for the normal eating response to sweet stimuli. To test this hypothesis, we measured the ratio of dihydroxyphenylacetic acid (DOPAC) to dopamine (DA) in forebrain DA terminal fields during the sham feeding of sucrose (1-40%) by rats after 17 hr of food deprivation. After 9 min of sham feeding 10% or 40% sucrose, DOPAC/DA increased in the hypothalamus, but not in other forebrain regions including the n. accumbens, amygdala, and pyriform cortex. This increase in hypothalamic DOPAC/DA did not occur after 9 min of sham feeding 1%, 1.25%, or 2.5% sucrose. The increased DA metabolism required that sham feeding of 10% or 40% sucrose be maintained for longer than 3 min, because no increase of DOPAC/DA was observed in any forebrain region after 3 min of sham feeding. These results are strong evidence that hypothalamic DA mechanisms are activated by the sham feeding of sucrose solutions and they support the hypothesis that central DA mechanisms are necessary for the normal eating response to sweet stimuli.
近期的药理学实验表明，中枢多巴胺能（DA）机制对于对甜味刺激的正常进食反应是必要的。为了验证这一假设，我们在大鼠禁食17小时后假饲蔗糖（1%-40%）期间，测量了前脑DA终末区域中二羟基苯乙酸（DOPAC）与多巴胺（DA）的比值。在假饲10%或40%蔗糖9分钟后，下丘脑的DOPAC/DA升高，但在包括伏隔核、杏仁核和梨状皮质在内的其他前脑区域未升高。在假饲1%、1.25%或2.5%蔗糖9分钟后，下丘脑的DOPAC/DA未出现升高。DA代谢增加要求假饲10%或40%蔗糖持续超过3分钟，因为假饲3分钟后在前脑任何区域均未观察到DOPAC/DA升高。这些结果有力地证明，下丘脑DA机制被蔗糖溶液的假饲激活，并且支持了中枢DA机制对于对甜味刺激的正常进食反应是必要的这一假设。
