Kashimoto Rena, Furukawa Saya, Yamamoto Sakiya, Kamei Yasuhiro, Sakamoto Joe, Nonaka Shigenori, Watanabe Tomonobu M, Sakamoto Tatsuya, Sakamoto Hirotaka, Satoh Akira
Division of Earth, Life, and Molecular Sciences, Graduate School of Natural Science and Technology, Okayama University, Okayama 700-8530, Japan.
Department of Biological Sciences, Faculty of Science, Okayama University, Okayama 700-8530, Japan.
iScience. 2022 Jun 3;25(7):104524. doi: 10.1016/j.isci.2022.104524. eCollection 2022 Jul 15.
The morphology of collagen-producing cells and the structure of produced collagen in the dermis have not been well-described. This lack of insights has been a serious obstacle in the evaluation of skin regeneration. We succeeded in visualizing collagen-producing cells and produced collagen using the axolotl skin, which is highly transparent. The visualized dermal collagen had a lattice-like structure. The collagen-producing fibroblasts consistently possessed the lattice-patterned filopodia along with the lattice-patterned collagen network. The dynamics of this lattice-like structure were also verified in the skin regeneration process of axolotls, and it was found that the correct lattice-like structure was not reorganized after simple skin wounding but was reorganized in the presence of nerves. These findings are not only fundamental insights in dermatology but also valuable insights into the mechanism of skin regeneration.
真皮中产生胶原蛋白的细胞形态以及所产生胶原蛋白的结构尚未得到充分描述。这种认识上的不足一直是评估皮肤再生的严重障碍。我们利用高度透明的蝾螈皮肤成功地可视化了产生胶原蛋白的细胞和所产生的胶原蛋白。可视化的真皮胶原蛋白具有晶格状结构。产生胶原蛋白的成纤维细胞始终具有晶格状的丝状伪足以及晶格状的胶原蛋白网络。在蝾螈的皮肤再生过程中也证实了这种晶格状结构的动态变化，并且发现简单的皮肤创伤后正确的晶格状结构不会重新组织，而是在有神经存在的情况下重新组织。这些发现不仅是皮肤病学的基本见解，也是对皮肤再生机制的宝贵见解。
Zotero 插件
