大学生血小板单胺氧化酶活性与精神病倾向
Platelet MAO activity and psychosis proneness in college students.
作者信息
Yehuda R, Edell W S, Meyer J S
出版信息
Psychiatry Res. 1987 Feb;20(2):129-42. doi: 10.1016/0165-1781(87)90005-9.
A population of individuals potentially at risk for psychiatric disorders was identified by screening 633 college students using the Wisconsin Scales for psychosis proneness. Platelet monoamine oxidase (MAO) activity was measured in high-scoring individuals and controls using 14C-benzylamine. Males with deviant scores on the Perceptual Aberration-Magical Ideation Scale showed a bimodal distribution of platelet MAO activity. Kinetic analysis of platelets from probands with the highest and lowest levels of MAO activity in this group revealed differences in Vmax but not in Km. Since abnormal platelet MAO activity has been linked to psychiatric vulnerability, the results provide further support for the validity of the Wisconsin Scales as predictors of psychopathology.
通过使用威斯康星精神病态倾向量表对633名大学生进行筛查，确定了一组可能有精神疾病风险的人群。使用14C-苄胺对高分个体和对照组的血小板单胺氧化酶（MAO）活性进行了测量。在感知偏差-神奇观念量表上得分异常的男性血小板MAO活性呈双峰分布。对该组中MAO活性最高和最低水平的先证者的血小板进行动力学分析，结果显示最大反应速度（Vmax）存在差异，但米氏常数（Km）无差异。由于异常的血小板MAO活性与精神疾病易感性有关，这些结果为威斯康星量表作为精神病理学预测指标的有效性提供了进一步支持。
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