Abdieva Gulnora Abdullaevna, Patra Indrajit, Al-Qargholi Basim, Shahryari Taher, Chauhan Narendra Pal Singh, Moghaddam-Manesh Mohammadreza
Teaching Assistant, Department of Internal Medicine, Samarkand State Medical Institute, Samarkand, Uzbekistan.
An Independent Researcher, NIT, Durgapur, India.
Front Bioeng Biotechnol. 2022 Jun 8;10:861580. doi: 10.3389/fbioe.2022.861580. eCollection 2022.
Metal organic frameworks (MOFs) are a promising choice for antibacterial and antifungal activity due to their composition, unique architecture, and larger surface area. Herein, the ultrasonic method was used to synthesize the Cu/Zn-MOF material as an effective hybrid nanostructure with ideal properties. SEM images were used to investigate the product's morphology and particle size distribution. The XRD pattern revealed that the Cu/Zn hybrid MOF nanostructures had a smaller crystalline size distribution than pure Cu and Zn-MOF samples. Furthermore, the BET technique determined that the hybrid MOF nanostructures had a high specific surface area. TG analysis revealed that the hybrid MOF structures were more thermally stable than pure samples. The final product, with remarkable properties, was used as a new option in the field of antibacterial studies. Antibacterial activity was assessed using MIC and MBC against Gram negative and Gram positive strains, as well as antifungal activity using MIC and MFC. The antimicrobial properties of the synthesized Cu/Zn hybrid MOF nanostructures revealed that they were more effective than commercial drugs in some cases. This study's protocol could be a new strategy for introducing new hybrid nanostructures with specific applications.
金属有机框架材料(MOFs)由于其组成、独特的结构和较大的表面积,是抗菌和抗真菌活性的一个有前景的选择。在此,采用超声法合成了Cu/Zn-MOF材料,作为一种具有理想性能的有效杂化纳米结构。利用扫描电子显微镜(SEM)图像研究了产物的形态和粒径分布。X射线衍射(XRD)图谱表明,Cu/Zn杂化MOF纳米结构的晶体尺寸分布比纯Cu和Zn-MOF样品小。此外,BET技术测定杂化MOF纳米结构具有较高的比表面积。热重(TG)分析表明,杂化MOF结构比纯样品具有更高的热稳定性。最终产物具有显著的性能,被用作抗菌研究领域的一种新选择。使用最低抑菌浓度(MIC)和最低杀菌浓度(MBC)评估对革兰氏阴性菌和革兰氏阳性菌的抗菌活性,以及使用MIC和最低杀菌浓度(MFC)评估抗真菌活性。合成的Cu/Zn杂化MOF纳米结构的抗菌性能表明,在某些情况下它们比商业药物更有效。本研究的方案可能是引入具有特定应用的新型杂化纳米结构的一种新策略。