比较儿童和成人的输血反应：系统评价和荟萃分析。
Comparison of transfusion reactions in children and adults: A systematic review and meta-analysis.
机构信息
Department of Blood Transfusion, Children's Hospital of Nanjing Medical University, Nanjing, China.
出版信息
Pediatr Blood Cancer. 2022 Sep;69(9):e29842. doi: 10.1002/pbc.29842. Epub 2022 Jun 27.
BACKGROUND
There are no international standards or normalizations for diagnosing and treating complications from blood transfusions. We comprehensively compared the incidence of adverse blood transfusions in children and adults.
METHODS
Available literature on blood transfusion adverse reactions in children and adults prior to November 27, 2021 was collected from several electronic databases. This meta-analysis was performed using Revman 5.2 and Stata 15.1.
RESULTS
The incidence of transfusion reactions is higher in children than in adults. Children transfused with red blood cells and platelets exhibited a higher incidence of transfusion reaction than that of adults. Moreover, the incidence of allergic and febrile non-hemolytic transfusion reactions was significantly higher in children than in adults. The incidence of some rare transfusion reactions was also significantly higher in children than in adults.
CONCLUSION
The incidence of transfusion reactions in children and adults is varied. Guidelines for children are necessary.
背景
目前尚无国际标准或规范可用于诊断和治疗输血相关并发症。我们全面比较了儿童和成人输血不良反应的发生率。
方法
从多个电子数据库中收集了截至 2021 年 11 月 27 日关于儿童和成人输血不良反应的现有文献。使用 Revman 5.2 和 Stata 15.1 进行了这项荟萃分析。
结果
与成人相比，儿童的输血反应发生率更高。输注红细胞和血小板的儿童输血反应发生率高于成人。此外，儿童过敏和发热性非溶血性输血反应的发生率明显高于成人。一些罕见输血反应的发生率也明显高于成人。
结论
儿童和成人的输血反应发生率存在差异。有必要为儿童制定指南。
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