Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Højbakkegaard Allé 5, 2630, Taastrup, Denmark.
BMC Res Notes. 2022 Jun 27;15(1):226. doi: 10.1186/s13104-022-06116-x.
Osteoarthritis (OA) is a significant health issue in humans as well as horses. Experimental models of equine carpal OA have been used to investigate OA pathogenesis and potential therapeutic candidates. A 5-scale scoring system (OARSI) for macroscopic pathological cartilage changes already exists, but there is a need for a scoring system with better differentiation of severity. The aim of this study was therefore to develop and validate such a scoring system.
New scoring system were developed for cartilage erosions (Copenhagen Equine Total Cartilage Score, CEqTCS) along with synovial membrane pathology and osteochondral fragment healing (Copenhagen Equine Carpal Osteoarthritis Score, CEqCOAS). For the CEqTCS there was excellent intraclass agreement (ICC = 0.993; CI 0.985-0.996; p = 1.08e-31) and consistency (ICC = 0.992; CI 0.985-0.996; p = 4.61e-31), as well as excellent interclass agreement (ICC = 0.974; CI 0.948-0.987, p = 2e-22) and consistency (ICC = 0.973; CI 0.946-0.987; p = 2.77e-22), while the OARSI system had moderate (κ = 0.47) and weak (κ = 0.28) inter- and intra-class agreement, respectively. The OARSI score and the CEqTCS correlated excellently, but every OARSI grade encompassed a wide range of CEqTCS grades. The new score for assessment of equine OA provides means to a better differentiation of OA changes than the existing OARSI system.
骨关节炎（OA）是人类和马的重大健康问题。马腕关节炎的实验模型已被用于研究 OA 的发病机制和潜在的治疗候选药物。已经存在一种用于宏观病理软骨变化的 5 级评分系统（OARSI），但需要一种具有更好严重程度区分能力的评分系统。因此，本研究的目的是开发和验证这种评分系统。
本研究开发了一种新的软骨侵蚀评分系统（哥本哈根马全软骨评分，CEqTCS），以及滑膜病理和骨软骨碎片愈合评分系统（哥本哈根马腕关节炎评分，CEqCOAS）。对于 CEqTCS，具有极好的组内一致性（ICC=0.993；CI 0.985-0.996；p=1.08e-31）和一致性（ICC=0.992；CI 0.985-0.996；p=4.61e-31），以及极好的组间一致性（ICC=0.974；CI 0.948-0.987，p=2e-22）和一致性（ICC=0.973；CI 0.946-0.987；p=2.77e-22），而 OARSI 系统具有中度（κ=0.47）和弱（κ=0.28）的组内和组间一致性。OARSI 评分与 CEqTCS 相关性极好，但每个 OARSI 等级都涵盖了广泛的 CEqTCS 等级。用于评估马 OA 的新评分系统提供了一种比现有 OARSI 系统更好地区分 OA 变化的方法。
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