Cavagna Mario, Petersen Claudia G, Mauri Ana L, Oliveira João Batista A, Baruffi Ricardo R L, Franco José G
Center for Human Reproduction Prof. Franco Jr, Ribeirao Preto, SP, Brazil.
Paulista Center for Diagnosis Research and Training, Ribeirao Preto, SP, Brazil.
JBRA Assist Reprod. 2014 Dec 27;18(4):136-138. doi: 10.5935/1518-0557.20140019.
To determine whether administration of progesterone on the day of oocyte retrieval may reverse accumulation of fluid in the endometrial cavity.
A total of 50 patients who underwent assisted reproductive technology (ART) cycles with endometrial cavity fluid (ECF) observed by ultrasound at the time of oocyte retrieval were included. Upon the identification of ECF, vaginal administration of natural progesterone was started. Two days later, the endometrial cavity was re-evaluated, and embryo transfer was performed in the absence of ECF.
ECF was absent two days after administration of vaginal progesterone in 47 of the 50 patients (94%). ECF persisted in 3 of the 50 patients (6%). The clinical pregnancy rate per transfer was 34.0%, and the implantation rate was 21.6%.
Our data suggest that, in the presence of ECF, administration of intravaginal progesterone in ART cycles must be initiated on the day of follicle aspiration to reverse ECF and to avoid the deleterious effects of fluid on the blastocyst-endometrial interaction.
确定在取卵日给予孕酮是否可逆转子宫内膜腔内液体的积聚。
共纳入50例接受辅助生殖技术（ART）周期治疗的患者，这些患者在取卵时经超声观察到存在子宫内膜腔积液（ECF）。在确认存在ECF后，开始经阴道给予天然孕酮。两天后，重新评估子宫内膜腔，在无ECF的情况下进行胚胎移植。
50例患者中有47例（94%）在经阴道给予孕酮两天后ECF消失。50例患者中有3例（6%）ECF持续存在。每次移植的临床妊娠率为34.0%，着床率为21.6%。
我们的数据表明，在存在ECF的情况下，ART周期中必须在卵泡抽吸日开始经阴道给予孕酮，以逆转ECF并避免液体对囊胚-子宫内膜相互作用的有害影响。
