Wang Xue-Mei, Nuriddin Hailigulli, Liu Yu, Maimaiti Gulibaha, Yan Mei
First Department of Internal Pediatrics, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2022 Jun 15;24(6):687-692. doi: 10.7499/j.issn.1008-8830.2112150.
To examine the expression of serum thyroglobulin antibody (TGAb) and thyroid peroxidase antibody (TPOAb) in children with immune thrombocytopenia (ITP).
A total of 120 children with ITP who were admitted from October 2019 to October 2021 were enrolled as the ITP group. A total of 60 children without ITP were enrolled as the non-ITP group. According to the clinical classification of ITP, the children in the ITP group were further divided into a newly diagnosed ITP group, a persistent ITP group, and a chronic ITP group. The clinical data were compared between the ITP group and the non-ITP group and between the children with different clinical classifications of ITP. The expression levels of serum TGAb and TPOAb in children with ITP were measured and their association with the clinical classification of ITP was analyzed.
Compared with the non-ITP group, the ITP group had significantly lower levels of CD3, CD4, and platelet count (PLT) and significantly higher levels of CD8, TGAb, and TPOAb (<0.05). The children with chronic ITP had significantly lower levels of CD3, CD4, and PLT and significantly higher levels of CD8, TGAb, and TPOAb than those with newly diagnosed ITP or persistent ITP (<0.05). The logistic regression analysis showed that CD3, CD4, CD8, TGAb, and TPOAb were the influencing factors for chronic ITP (<0.05). A decision curve was plotted, and the results showed that TGAb combined with TPOAb within the high-risk threshold range of 0.0-1.0 had a net benefit rate of >0 in evaluating the clinical classification of ITP in children.
TGAb and TPOAb are abnormally expressed in children with ITP and are associated with the clinical classification of ITP in children.
检测免疫性血小板减少症（ITP）患儿血清甲状腺球蛋白抗体（TGAb）和甲状腺过氧化物酶抗体（TPOAb）的表达情况。
选取2019年10月至2021年10月收治的120例ITP患儿作为ITP组，另选取60例非ITP患儿作为非ITP组。根据ITP的临床分类，将ITP组患儿进一步分为新诊断ITP组、持续性ITP组和慢性ITP组。比较ITP组与非ITP组以及不同临床分类的ITP患儿之间的临床资料。检测ITP患儿血清TGAb和TPOAb的表达水平，并分析其与ITP临床分类的相关性。
与非ITP组相比，ITP组患儿的CD3、CD4水平及血小板计数（PLT）显著降低，CD8、TGAb及TPOAb水平显著升高（<0.05）。慢性ITP患儿的CD3、CD4及PLT水平显著低于新诊断ITP或持续性ITP患儿，而CD8、TGAb及TPOAb水平显著高于新诊断ITP或持续性ITP患儿（<0.05）。Logistic回归分析显示，CD3、CD4、CD8、TGAb及TPOAb是慢性ITP的影响因素（<0.05）。绘制决策曲线，结果显示在0.0 - 1.0的高风险阈值范围内，TGAb联合TPOAb在评估儿童ITP临床分类时的净效益率>0。
TGAb和TPOAb在ITP患儿中表达异常，且与儿童ITP的临床分类相关。
