GenPhySE, Université de Toulouse, INRAE, ENVT, Castanet Tolosan, France.
Toxalim, Université de Toulouse, INRAE, ENVT, INP-Purpan, UPS, Toulouse, France.
PLoS One. 2022 Jun 28;17(6):e0255707. doi: 10.1371/journal.pone.0255707. eCollection 2022.
Understanding the evolution of fatty liver metabolism of ducks is a recurrent issue for researchers and industry. Indeed, the increase in weight during the overfeeding period leads to an important change in the liver metabolism. However, liver weight is highly variable at the end of overfeeding within a batch of animals reared, force-fed and slaughtered in the same way. For this study, we performed a proton nuclear magnetic resonance (1H-NMR) analysis on two classes of fatty liver samples, called low-weight liver (weights between 550 and 599 g) and high-weight liver (weights above 700 g). The aim of this study was to identify the differences in metabolism between two classes of liver weight (low and high). Firstly, the results suggested that increased liver weight is associated with higher glucose uptake leading to greater lipid synthesis. Secondly, this increase is probably also due to a decline in the level of export of triglycerides from the liver by maintaining them at high hepatic concentration levels, but also of hepatic cholesterol. Finally, the increase in liver weight could lead to a significant decrease in the efficiency of aerobic energy metabolism associated with a significant increase in the level of oxidative stress. However, all these hypotheses will have to be confirmed in the future, by studies on plasma levels and specific assays to validate these results.
研究人员和业界一直在关注鸭子脂肪肝代谢的演变。确实，在过量喂食期间体重的增加会导致肝脏代谢发生重要变化。然而，在以相同方式饲养、强制喂食和屠宰的一批动物中，过量喂食结束时肝脏的重量变化很大。在这项研究中，我们对两类脂肪肝样本进行了质子核磁共振（1H-NMR）分析，这两类样本分别称为低重量肝脏（重量在 550 到 599 克之间）和高重量肝脏（重量超过 700 克）。本研究的目的是确定两种不同肝脏重量（低重量和高重量）之间的代谢差异。首先，研究结果表明，肝脏重量的增加与葡萄糖摄取增加有关，从而导致脂质合成增加。其次，这种增加可能还归因于肝脏中甘油三酯的输出水平下降，尽管肝脏中胆固醇的浓度水平也很高，但它们仍得以维持。最后，肝脏重量的增加可能导致与氧化应激水平显著增加相关的有氧能量代谢效率显著降低。然而，所有这些假设都需要通过对血浆水平的研究和特定的验证实验来进一步证实。
