Meng T T, Miao N, Zheng H, Wang F Z, Yin Z D, Shen L P, Wang Y, Jia J D, Kong Y Y, Zhang Guomin
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China Liver Research Center, Beijing Friendship Hospital, Capital Medical University & National Clinical Research Center for Digestive Disease, Beijing 100050, China Clinical Epidemiology and EBM Unit, Beijing Friendship Hospital, Capital Medical University & Beijing Clinical Research Institute, Beijing 100050, China.
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 May 20;30(5):534-540. doi: 10.3760/cma.j.cn501113-20220303-00097.
To understand the awareness rate and its influencing factors of their HBV infection status among HBsAg-positive persons aged 15-69 years in China. A cross-sectional design was used to conduct a questionnaire survey on the awareness of their infection status among HBsAg-positive persons aged 15-69 years who were identified in the 2020 national hepatitis B seroepidemiology survey. The awareness rate of the whole respondent and respondents with different characteristics were described, and the differences were compared with the test. The logistic regression model was used to analyze the factors influencing the awareness rate. The overall awareness rate among the respondents was 43.10% (1 828/4 241). The awareness rate was lower in males than in females (41.30% 44.65%). The awareness rate was lower in the 60-69-years-old age group than in other age groups (30.38% 36.77%-57.58%). The awareness rate was lower in rural areas than in urban areas (39.43% 47.32%). The awareness rate was lower in regions with a per capita gross domestic product (GDP) below RMB 54 000 than in regions with a per capita GDP of RMB 54 000 and above (36.81% 41.61%-50.30%). The awareness rate was lower in respondents without other liver diseases than with other liver diseases (41.52% 60.68%). The awareness rate was lower in respondents without a family history of hepatitis B-related disease or unknown family history than with a family history (43.58% 68.26%; 24.71% vs. 68.26%). Multivariate logistic regression analysis showed that male [odds ratio ()=0.841, 95% confidence interval (: 0.734-0.964], high school and below [primary school and below, junior middle school, high school/technical secondary school, (95%): 0.247 (0.190-0.321), 0.451 (0.352-0.577), 0.634 (0.486-0.827)], rural areas (=0.822, 95%: 0.715-0.945) and regions with a per capita GDP below RMB 80 000 [54 000-80 000, (95%): 0.810 (0.688-0.954), below RMB 54 000, (95%): 0.793 (0.669-0.941)] were the negative factors influencing the awareness rate. While 30-39-years-old (=2.089, 95%: 1.626-2.683) and 40-49-years-old (=1.590, 95%: 1.250-2.023) age groups, with other liver diseases (=2.244, 95%: 1.754-2.871) and family history related to hepatitis B (=2.688, 95%: 2.242-3.223) were the positive factors influencing the awareness rate. The overall awareness rate of their infection status among HBsAg-positive persons aged 15-69 years is 43.10% in China. Health promotion and coverage expansion on HBV screening should be further strengthened to achieve the proposed World Health Organization's target of 90% HBV infection diagnosis rate by 2030.
了解中国15 - 69岁HBsAg阳性者对自身乙肝病毒(HBV)感染状况的知晓率及其影响因素。采用横断面设计,对在2020年全国乙肝血清流行病学调查中被确定的15 - 69岁HBsAg阳性者进行关于其感染状况知晓情况的问卷调查。描述了全部受访者及不同特征受访者的知晓率,并通过t检验比较差异。使用逻辑回归模型分析影响知晓率的因素。受访者的总体知晓率为43.10%(1828/4241)。男性知晓率低于女性(41.30%对44.65%)。60 - 69岁年龄组的知晓率低于其他年龄组(30.38%对36.77% - 57.58%)。农村地区的知晓率低于城市地区(39.43%对47.32%)。人均国内生产总值(GDP)低于54000元地区的知晓率低于人均GDP 54000元及以上地区(36.81%对41.61% - 50.30%)。无其他肝脏疾病的受访者知晓率低于有其他肝脏疾病的受访者(41.52%对60.68%)。无乙肝相关疾病家族史或家族史不明的受访者知晓率低于有家族史的受访者(43.58%对68.26%;24.71%对68.26%)。多因素逻辑回归分析显示,男性[比值比(OR) = 0.841,95%置信区间(CI):0.734 - 0.964]、高中及以下学历[小学及以下、初中、高中/中专,OR(95%CI):0.247(0.190 - 0.321)、0.451(0.352 - 0.577)、0.634(0.486 - 0.827)]、农村地区(OR = 0.822,95%CI:0.715 - 0.945)以及人均GDP低于80000元地区[54000 - 80000元,OR(95%CI):0.810(0.688 - 0.954)、低于54000元,OR(95%CI):0.793(0.669 - 0.941)]是影响知晓率的负向因素。而30 - 39岁(OR = 2.089,95%CI:1.626 - 2.683)和40 - 49岁(OR = 1.590,95%CI:1.250 - 2.023)年龄组、有其他肝脏疾病(OR = 2.244,95%CI:1.754 - 2.871)以及有乙肝相关家族史(OR = 2.688,95%CI:2.242 - 3.223)是影响知晓率的正向因素。中国15 - 69岁HBsAg阳性者对其感染状况的总体知晓率为43.10%。应进一步加强乙肝病毒筛查的健康促进和扩大覆盖范围,以实现世界卫生组织提出的到2030年乙肝病毒感染诊断率达到90%的目标。