Sha C X, Ju L L, Zhou P, Yao D F, Yao Min
Department of Immunology, Medical School of Nantong University, Nantong 226001, China.
Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong 226001, China.
Zhonghua Gan Zang Bing Za Zhi. 2022 May 20;30(5):564-568. doi: 10.3760/cma.j.cn501113-20211011-00503.
Today, nonalcoholic fatty liver disease remains the most dominant chronic liver disease. Cyclic guanosine monophosphate-adenosine monosphosphate synthase (cGAS) is a cytosolic DNA sensor that catalyzes the synthesis of cyclic guanosine monophosphate, activates stimulator of interferon genes (STING), and releases type-I interferon cytokines to trigger immune responses. Exogenous or endogenous DNA acts as a cGAS ligand to activate the cGAS-STING signaling pathway, which plays a role in hepatitis, nonalcoholic fatty liver disease, liver cancer and other diseases, and affects liver disease progression and metabolism through mechanisms such as autophagy. This article reviews the activation of cGAS-STING pathway and its molecular immunological role in nonalcoholic fatty liver disease progression.
如今，非酒精性脂肪性肝病仍然是最主要的慢性肝病。环磷酸鸟苷-腺苷酸合成酶（cGAS）是一种胞质DNA传感器，可催化环磷酸鸟苷的合成，激活干扰素基因刺激因子（STING），并释放I型干扰素细胞因子以触发免疫反应。外源性或内源性DNA作为cGAS配体激活cGAS-STING信号通路，该通路在肝炎、非酒精性脂肪性肝病、肝癌等疾病中发挥作用，并通过自噬等机制影响肝病进展和代谢。本文综述了cGAS-STING通路的激活及其在非酒精性脂肪性肝病进展中的分子免疫学作用。
