Zidrou Christiana, Vasiliadis Angelo V, Tsatlidou Maria, Charitoudis George, Beletsiotis Anastasios
2 Orthopaedic Department, G. Papageorgiou General Hospital, Thessaloniki, Greece.
School of Medicine, Aristotle University of Thessaloniki, University Campus, Thessaloniki, Greece.
J Frailty Sarcopenia Falls. 2022 Jun 1;7(2):81-87. doi: 10.22540/JFSF-07-081. eCollection 2022 Jun.
To evaluate the incidence of polypharmacy and the use of fall-risk-increasing drugs (FRIDs) in patients >65 years of age.
478 patients >65 years old, discharged from an Orthopaedic Department because of hip-fracture surgery, capable of walking before surgery, were included. The baseline characteristics of the patients and the total numbers of drugs and FRIDs were recorded from the electronic hospital registration system. Polypharmacy was defined as the average daily use of five or more drugs. The gender differences in drug prescriptions were calculated.
All the patients took medications except for eight (1.7%); 46% of the patients were taking <5 medications, while 386 (80.8%) were taking ≤3 FRIDs. The female patients were taking more drugs (5±2.7) and FRIDs (2.4±1.3) than the male ones (4.5±3 and 1.9±1.3) (both p<0.01). The average numbers of drugs and FRIDs prescribed at discharge were 4.9±2.8 and 2.3±1.3, respectively. The Barthel Index was higher for patients taking <5 drugs, while the length of hospital stay was greater for patients taking ≥5 medications. Increased age was associated with taking ≥5 medications (p<0.05).
Polypharmacy and FRID use are prevalent among patients over 65 years old who have been hospitalized and surgically treated because of hip fractures.
评估65岁以上患者多重用药的发生率以及增加跌倒风险药物（FRIDs）的使用情况。
纳入478例65岁以上因髋部骨折手术从骨科出院且术前能够行走的患者。从电子医院登记系统记录患者的基线特征、药物总数和FRIDs。多重用药定义为平均每日使用五种或更多药物。计算药物处方中的性别差异。
除8例（1.7%）患者外，所有患者均服用药物；46%的患者服用药物少于5种，而386例（80.8%）患者服用≤3种FRIDs。女性患者服用的药物（5±2.7种）和FRIDs（2.4±1.3种）比男性患者（4.5±3种和1.9±1.3种）更多（均p<0.01）。出院时开具的药物和FRIDs的平均数量分别为4.9±2.8种和2.3±1.3种。服用药物少于5种的患者Barthel指数较高，而服用≥5种药物的患者住院时间更长。年龄增加与服用≥5种药物相关（p<0.05）。
多重用药和FRIDs的使用在因髋部骨折住院并接受手术治疗的65岁以上患者中普遍存在。
