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[对居住在瓦尔马德拉(意大利北部伦巴第大区)焚烧炉附近人群死亡率和发病率的影响]

[Effects on mortality and morbidity among the population living close to the Valmadrera (Lombardy Region, Northern Italy) incinerator].

作者信息

Piccinelli Cristiano, Carnà Paolo, Amodio Emanuele, Cadum Ennio, Donato Francesco, Rognoni Magda, Vuono Marco, Cavalieri d'Oro Luca

机构信息

SSD epidemiologia e screening, CPO-AOU Città della salute e della scienza di Torino, Torino;

Dipartimento di scienze cliniche e biologiche, Università degli Studi di Torino.

出版信息

Epidemiol Prev. 2022 May-Jun;46(3):147-159. doi: 10.19191/EP22.3.A335.033.

Abstract

OBJECTIVES

assessment of the health effects on the resident population around the incinerator for municipal solid waste in Valmadrera (Lombardy Region, Northern Italy) in relation to the exposure level to the pollutants produced by the plant.

DESIGN

historical cohort study, based on the resident population from 2003 to 2016 in the study area. With a dispersion model, based on PM10 emitted by the plant, three areas of exposure (high, medium, low) were defined and, on the basis of the residence of the cohort, different exposure levels were attributed to the subjects. The association between level of exposure and health effects were estimated by comparing the high and medium exposure levels with the low exposure level, using a Cox model, adjusted for age and socioeconomic deprivation index.

MAIN OUTCOME MEASURES

mortality rates, hospitalization rates, cancer incidence rates, and perinatal outcomes were analysed for the main causes potentially associated with exposure to incineration plants.

RESULTS

the subjects enrolled in the cohort were 106,056 (1,000,242 person-years). There were no statistically significant excesses of risk for almost all the outcomes investigated. Excessive mortality and hospitalization were found for liver/biliary cancers (HR women: 2.57; 95%CI 1.15-2.79; HR men: 2.22; 95%CI 1.10-4, 84). In the municipality where the plant is located, an excess prevalence (OR 1.78; 95%CI 1.43-2.21) of hepatitis C was found.

CONCLUSIONS

the results suggest the absence of a relationship between residence in areas with different levels of pollutants emitted by the plant and the onset of almost all diseases. The associated causes do not have aetiological plausibility with exposure to pollutants from waste incineration. In particular, for liver/liver and biliary cancer, the association with infectious causes rather than exposure to environmental pollutants is more plausible.

摘要

目的

评估意大利北部伦巴第大区瓦尔马德拉市城市固体废弃物焚烧厂周边居民的健康影响,及其与该厂所产生污染物暴露水平的关系。

设计

基于2003年至2016年研究区域内居民的历史性队列研究。利用基于该厂排放的PM10的扩散模型,定义了三个暴露区域(高、中、低),并根据队列成员的居住情况,将不同的暴露水平归因于研究对象。通过比较高暴露水平和中等暴露水平与低暴露水平,并使用经年龄和社会经济剥夺指数调整的Cox模型,来估计暴露水平与健康影响之间的关联。

主要观察指标

分析了与焚烧厂暴露潜在相关的主要病因的死亡率、住院率、癌症发病率和围产期结局。

结果

队列中的研究对象有106,056人(1,000,242人年)。几乎所有所调查的结局均未发现具有统计学意义的风险增加。在肝癌/胆管癌方面发现了过高的死亡率和住院率(女性风险比:2.57;95%置信区间1.15 - 2.79;男性风险比:2.22;95%置信区间1.10 - 4.84)。在该厂所在的市镇,发现丙型肝炎患病率过高(比值比1.78;95%置信区间1.43 - 2.21)。

结论

结果表明,居住在该厂排放不同污染物水平的区域与几乎所有疾病的发病之间不存在关联。所涉病因与垃圾焚烧污染物暴露不存在病因学上的合理性。特别是对于肝癌/肝和胆管癌,与感染性病因而非环境污染物暴露的关联更具合理性。

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