一氧化氮在轻至中度强度循环运动时的肺弥散量的重测信度。

Test-retest reliability of lung diffusing capacity for nitric oxide during light to moderate intensity cycling exercise.

机构信息

Zurich University of Applied Sciences, School of Health Professions, Institute of Physiotherapy, Winterthur, Switzerland.

University of Zurich and University Hospital Zurich, Epidemiology, Biostatistics and Prevention Institute, Division of Occupational and Environmental Medicine, Zürich, Switzerland.

出版信息

Respir Physiol Neurobiol. 2022 Oct;304:103940. doi: 10.1016/j.resp.2022.103940. Epub 2022 Jun 28.

DOI:10.1016/j.resp.2022.103940

PMID:35777723

Abstract

This study examined test-retest reliability of single-breath lung diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO) during exercise. Sixteen healthy subjects (age 20-67 years) performed DLNO-DLCO tests during light and moderate intensity cycling exercise at 50% and 80% of individual anaerobic threshold (IAT). Primary endpoint was DLNO at 80% IAT. Precision of DLNO, DLCO, and alveolar volume was quantified by within-subject standard deviation (SD, measurement error) and intraclass correlation coefficients (ICC). Reproducibility was determined by SD* 2.77. Overall, reliability was excellent for all outcomes. SD and reproducibility for DLNO at 80% IAT were 4.6 and 12.7 mL.min.mmHg, and the ICC was 0.99 (95% confidence interval 0.98-0.99). Median breathlessness at 80% IAT was 4 (interquartile range 3-6) on a 0-10 scale. Our data suggest excellent reliability of single-breath DLNO during moderate intensity exercise, but perceived levels of breathlessness may limit its usefulness, especially at exercise intensities beyond IAT.

摘要

本研究旨在考察一氧化氮（DLNO）和一氧化碳（DLCO）单呼吸肺弥散量在运动中的重测信度。16 名健康受试者（年龄 20-67 岁）在 50%和 80%个体无氧阈（IAT）的轻中度踏车运动中进行了 DLNO-DLCO 测试。主要终点为 80%IAT 时的 DLNO。通过个体内标准差（SD，测量误差）和组内相关系数（ICC）来量化 DLNO、DLCO 和肺泡容积的精密度。通过 SD*2.77 来确定再现性。总体而言，所有结果的可靠性均极佳。80%IAT 时 DLNO 的 SD 和再现性分别为 4.6 和 12.7mL.min.mmHg，ICC 为 0.99（95%置信区间 0.98-0.99）。80%IAT 时的中位数呼吸困难程度为 0-10 刻度上的 4（四分位间距 3-6）。我们的数据表明，单呼吸 DLNO 在中等强度运动中具有极好的可靠性，但感知到的呼吸困难程度可能限制了其应用，尤其是在 IAT 以上的运动强度下。