Gold Coast University Hospital, 1 Hospital Blvd, Southport, QLD 4215, Australia; Griffith University, Southport, QLD 4215, Australia.
University of Queensland, St Lucia, QLD 4072, Australia.
Clin Neurol Neurosurg. 2022 Sep;220:107341. doi: 10.1016/j.clineuro.2022.107341. Epub 2022 Jun 21.
Nocardia is a Gram-positive weakly acid-fast bacterium that is ubiquitous in the environment. It represents a rare cause of infection in humans and typically causes pulmonary, cutaneous, or central nervous system (CNS) infections. CNS nocardiosis has very poor prognosis, especially in immunocompromised hosts. Nocardia terpenica is a species of Nocardia consisting of two strains that were reclassified from Nocardia brasiliensis in 2007. We report the second case of CNS Nocardia terpenica infection, and the first case of cerebral abscess from Nocardia terpenica. This report raises the index of suspicion for nocardiosis when evaluating contrast-enhancing CNS lesions, points out the capability of this species for CNS spread, and shares our experience regarding management and prognosis.
奴卡菌是一种革兰阳性、弱抗酸性的细菌，广泛存在于环境中。它是人类感染的罕见病因，通常引起肺部、皮肤或中枢神经系统（CNS）感染。CNS 奴卡菌病的预后非常差，尤其是在免疫功能低下的宿主中。特内氏奴卡菌是奴卡菌属的一个种，由两个菌株组成，于 2007 年从巴西奴卡菌中重新分类。我们报告了第二例 CNS 特内氏奴卡菌感染，也是首例由特内氏奴卡菌引起的脑脓肿。该报告在评估增强 CNS 病变时提高了对奴卡菌病的怀疑指数，指出了该菌种向 CNS 扩散的能力，并分享了我们在管理和预后方面的经验。
