Acar Sencan, Arat Mutlu, Tecimer Tulay, Yalcin Polat Kamil, Akyildiz Murat
Department of Gastroenterology and Organ Transplantation Center, Sakarya University Faculty of Medicine, Sakarya, Turkey.
Department of Haematology and Bone Marrow Transplantation Unit, Bilim University Faculty of Medicine, Sisli Florence Nightingale Hospital, Istanbul, Turkey.
Hepatol Forum. 2022 Jan 10;3(1):30-32. doi: 10.14744/hf.2021.2021.0006. eCollection 2022 Jan.
Graft Versus Host Disease (GVHD) is a severe immunological-clinicopathological condition mediated by healthy T-lymphocytes in donor tissue against the immunosuppressed host tissue and rarely seen after solid organ transplantation (SOT). A 72-year old male patient underwent cadaveric liver transplantation. On day 34 of the postoperative follow-up, the patient developed fever, generalized skin rash and hemorrhagic lesions in the oropharynx. Skin biopsy was consistent with GVHD. Despite high-dose corticosteroid treatment, he died on postoperative day 51. Although it is seen rarely after liver transplantation, GVHD is an important clinical entity for which early diagnosis is critical due to its high rates of mortality.
移植物抗宿主病（GVHD）是一种严重的免疫 - 临床病理状况，由供体组织中的健康T淋巴细胞介导，针对免疫抑制的宿主组织，在实体器官移植（SOT）后很少见。一名72岁男性患者接受了尸体肝脏移植。术后随访第34天，患者出现发热、全身性皮疹和口咽部出血性病变。皮肤活检符合GVHD。尽管进行了大剂量皮质类固醇治疗，他仍在术后第51天死亡。虽然GVHD在肝移植后很少见，但由于其高死亡率，它是一个早期诊断至关重要的重要临床实体。
