探讨美国印第安女性乳腺癌的临床风险因素。

Exploring Clinical Risk Factors for Breast Cancer Among American Indian Women.

机构信息

Department of Indigenous Health, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, United States.

Turtle Mountain Community College, Belcourt, ND, United States.

出版信息

Front Public Health. 2022 Jun 17;10:840280. doi: 10.3389/fpubh.2022.840280. eCollection 2022.

DOI:10.3389/fpubh.2022.840280

PMID:35784224

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9247609/

Abstract

OBJECTIVE

Very little is known about the breast cancer risk profile among American Indian women. Previous research shows that the proportion of American Indian/Alaska Native women with baseline characteristics (commonly known breast cancer risk factors) differs from other ethnicities. This retrospective case control study was designed to the explore the association of these factors among American Indian women with and without breast cancer.

METHODS

Cases and controls were retrospectively selected from the medical records of American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND. For each woman with breast cancer ( = 141), two controls were selected when possible ( = 278). Risk factors examined included woman's age, age at first live birth, age of menarche, the number of previous benign breast biopsies, the total number of first-degree relatives with breast cancer, body mass index and parity. Odds ratios and 95% confidence intervals were calculated using logistic regression.

RESULTS

Many of the associations found among American Indian women who obtained their health care from Quentin N. Burdick Memorial Health Care Facility (Indian Health Service) in Belcourt, ND, between risk factors commonly identified in other populations and breast cancer were weakly positive. Nulliparity was the only risk factor to consistently show a positive significant association (OR = 2.87, 95% CI 1.16-0.7.12).

CONCLUSION

Disparities in breast cancer incidence, mortality and screening among Northern Plains American Indian emphasize the need to better understand the risk factors associated with breast cancer in this population. Based on the results of this study, the value of current risk prediction models in American Indian communities is uncertain and clinicians should be cautious in using these models to inform American Indian patients of their risk for breast cancer.

摘要

目的

关于美国印第安女性的乳腺癌风险概况知之甚少。先前的研究表明，具有基线特征（通常称为乳腺癌危险因素）的美国印第安/阿拉斯加原住民女性的比例与其他族裔不同。这项回顾性病例对照研究旨在探讨这些因素与患有和不患有乳腺癌的美国印第安女性之间的关联。

方法

从在北达科他州贝尔库特的昆廷·N·伯迪克纪念医疗保健设施（印第安人健康服务）获得医疗保健的美国印第安女性的病历中回顾性选择病例和对照。对于每一位患有乳腺癌的女性（n=141），尽可能选择两位对照（n=278）。检查的危险因素包括女性的年龄、首次活产年龄、初潮年龄、先前良性乳腺活检的次数、有乳腺癌的一级亲属总数、体重指数和产次。使用逻辑回归计算比值比和 95%置信区间。