Zhang Xiaoying, Song Yi-Chuan, Yang De-Gang, Liu Hong-Wei, Liu Song-Huai, Li Xiao-Bing, Li Jian-Jun
School of Rehabilitation Medicine, Capital Medical University, Beijing, China.
China Rehabilitation Science Institute, Beijing, China.
Front Neurosci. 2022 Jun 10;16:860127. doi: 10.3389/fnins.2022.860127. eCollection 2022.
In this study, the vocal intonation therapy (VIT) was compared with the standard respiratory therapy for people suffering from respiratory dysfunction as a result of cervical spinal cord injury (CSCI) to observe its effect on vocal quality. Thirty patients with vocal dysfunction after CSCI with the injury time of more than 3 months were screened for inclusion in the trial, and 18 patients completed the 12-weeks, each participant had 60 sessions in total in the clinical trial. All patients were allocated to the intervention group or the control group. The intervention group received VIT training and the control group received respiratory phonation therapy. Both groups were trained by professional therapists, and the training time was 30 min/day, 5 days/week, for 60 sessions for each group in a total of 12 weeks. In the Baseline (T0), mid-intervention period (after 6 weeks, T1), and after intervention (after 12 weeks, T2), the vocal quality of the two groups of patients was tested with a computer-aided real-time audio analyzer 2.1.6 (Adobe Systems, United States) for Sing-SPL ( < 0.0001), Speech-SPL ( < 0.0001), SNL ( < 0.0001), and F0 ( < 0.0001) of the intervention group were significantly improved compared with the control group. In comparing the spectrometry analysis of vocal quality for the 2 groups of participants, there was a significant difference in the results of Sing-SPL and Speech-SPL acoustic analysis in the intervention group of patients at T2 (after 12 weeks) compared to the control group. Vocal intonation therapy-music therapy can improve the speech sound quality of cervical CSCI patients and provide CSCI patients with a practical, highly operable treatment that has both functional training effects and can bring a pleasant experience that can be promoted in the medical field. This study was approved by the Ethics Committee of China Rehabilitation Research Center (CRRC) (approval No. 2019-83-1) on May 20th, 2019. It was registered with the National Health Security Information Platform, medical research registration, and filing information system (Registration No. MR-11-21-011802) on January 28th, 2021.
在本研究中，将语音语调疗法（VIT）与针对因颈脊髓损伤（CSCI）导致呼吸功能障碍的患者的标准呼吸疗法进行比较，以观察其对嗓音质量的影响。筛选出30例CSCI后嗓音功能障碍且损伤时间超过3个月的患者纳入试验，18例患者完成了为期12周的试验，每位参与者在临床试验中总共进行60次治疗。所有患者被分配到干预组或对照组。干预组接受VIT训练，对照组接受呼吸发声疗法。两组均由专业治疗师进行训练，训练时间为每天30分钟，每周5天，每组共60次治疗，为期12周。在基线期（T0）、干预中期（6周后，T1）和干预后（12周后，T2），使用计算机辅助实时音频分析仪2.1.6（美国Adobe系统公司）对两组患者的嗓音质量进行测试，干预组的歌唱声压级（<0.0001）、言语声压级（<0.0001）、噪声和谐波比（<0.0001）和基频（<0.0001）与对照组相比均有显著改善。在比较两组参与者的嗓音质量频谱分析时，干预组患者在T2（12周后）的歌唱声压级和言语声压级声学分析结果与对照组相比存在显著差异。语音语调疗法——音乐疗法可以改善颈髓损伤患者的语音质量，为颈髓损伤患者提供一种实用、操作性强的治疗方法，既具有功能训练效果，又能带来愉悦体验，可在医学领域推广。本研究于2019年5月20日获得中国康复研究中心（CRRC）伦理委员会批准（批准号2019 - 83 - 1）。于2021年1月28日在国家医保信息平台、医学研究登记备案信息系统注册（注册号MR - 11 - 21 - 011802）。
