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家庭经皮穴位电刺激治疗正常高值血压:一项随机对照试验。

Home-based transcutaneous electrical acupoint stimulation for high-normal blood pressure: A randomized controlled trial.

机构信息

International Acupuncture and Moxibustion Innovation Institute, Beijing University of Chinese Medicine, Chaoyang District, Beijing, China.

School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Chaoyang District, Beijing, China.

出版信息

J Clin Hypertens (Greenwich). 2022 Aug;24(8):984-992. doi: 10.1111/jch.14496. Epub 2022 Jul 4.

Abstract

The authors investigated the effectiveness of home-based transcutaneous electrical acupoint stimulation (TEAS) combined with lifestyle modification on blood pressure (BP) control and explored the feasibility of the trial design in this prospective, randomized controlled trial. The authors recruited individuals with high-normal BP who had a systolic blood pressure (SBP) of 120-139 mm Hg and a diastolic blood pressure (DBP) of 80-89 mm Hg, or both. Participants were randomly assigned to receive either lifestyle modification combined with TEAS four times weekly for 12 weeks at home (intervention group) or solely lifestyle modification (control group). The primary outcome was the change in mean SBP at week 12 from the baseline measurement. A total of 60 participants were randomized in a 1:1 ratio, and an intention-to-treat analysis was performed on all of the outcomes. The mean difference in the change in SBP for the intervention group (compared to the control) at week 12 was -3.85 mm Hg (95% CI: -7.58 to -.12; p = .043); for the DBP, the change was -2.27 mm Hg (95% CI: -5.76 to 1.23; p = .199). There was no difference in the proportion of progression to hypertension, quality of life, body mass index (BMI) or waist circumference. In addition, two participants reported TEAS-related adverse events. The authors found a reduction in SBP control in the pragmatic, home-based intervention by using TEAS combined with lifestyle modification in adults with high-normal BP. Trial Registration: The study was registered in the Chinese Clinical Trial Registry (ChiCTR 1900024982) on August 6, 2019.

摘要

作者研究了家庭经皮穴位电刺激(TEAS)联合生活方式改变对血压(BP)控制的有效性,并在这项前瞻性、随机对照试验中探讨了试验设计的可行性。作者招募了收缩压(SBP)为 120-139mmHg 和舒张压(DBP)为 80-89mmHg 或两者均升高的正常高值血压患者。参与者被随机分配接受每周在家接受 TEAS 四次共 12 周的生活方式改变(干预组)或仅接受生活方式改变(对照组)。主要结局是从基线测量开始第 12 周的平均 SBP 变化。共有 60 名参与者以 1:1 的比例随机分组,对所有结局进行意向治疗分析。干预组(与对照组相比)第 12 周 SBP 变化的平均差异为-3.85mmHg(95%CI:-7.58 至 -.12;p=0.043);DBP 的变化为-2.27mmHg(95%CI:-5.76 至 1.23;p=0.199)。高血压进展的比例、生活质量、体重指数(BMI)或腰围均无差异。此外,有 2 名参与者报告了与 TEAS 相关的不良事件。作者发现,在正常高值血压成年人中,使用 TEAS 联合生活方式改变的实用、家庭为基础的干预措施可降低 SBP 控制水平。试验注册:该研究于 2019 年 8 月 6 日在中国临床试验注册中心(ChiCTR1900024982)注册。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/013e/9380160/132077c55c28/JCH-24-984-g002.jpg

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