在意大利北部，疑似细菌性角膜炎应给予何种经验性治疗？

What empiric treatment should be given for suspected bacterial keratitis in Northern Italy?

机构信息

Department of Medical and Surgical Specialties, Radiological Specialties and Public Health, 9297University of Brescia, ASST Spedali Civili, Brescia, Italy.

Department of Molecular and Translational Medicine, Institute of Microbiology, University of Brescia-ASST Spedali Civili, Brescia, Italy.

出版信息

Eur J Ophthalmol. 2022 Nov;32(6):NP95-NP97. doi: 10.1177/11206721221112519. Epub 2022 Jul 5.

DOI:10.1177/11206721221112519

PMID:35791504

Abstract

There is a lack of epidemiological studies reporting bacteria profiles, susceptibility, and suggested empiric (first line) treatment in Northern Italy. Our internal audit of corneal scraping for microbial keratitis at University of Brescia reports 116 bacterial strains isolated between January 1, 2013, and December 31, 2020. All cases had at least an epithelial defect of 1 mm in diameter. 36.2% (42) were Gram-positive, while 63.7% (74) Gram negative. In our results Gram-negatives are sensitive to ciprofloxacin in 94.5% and Pseudomonas in 95%. Grampositives are sensitive to teicoplanin in 91,1%. Those data may help to establish empiric treatment in case of bacterial keratitis.

摘要

意大利北部缺乏报告细菌谱、药敏性和推荐经验性（一线）治疗的流行病学研究。我们对布雷西亚大学微生物角膜炎刮片的内部审计报告了 2013 年 1 月 1 日至 2020 年 12 月 31 日期间分离的 116 株细菌。所有病例的上皮缺损直径至少为 1 毫米。36.2%（42 株）为革兰阳性菌，63.7%（74 株）为革兰阴性菌。在我们的结果中，革兰阴性菌对环丙沙星的敏感性为 94.5%，对铜绿假单胞菌的敏感性为 95%。革兰阳性菌对替考拉宁的敏感性为 91.1%。这些数据可能有助于在细菌性角膜炎的情况下建立经验性治疗。