体内心脏的1H磁共振成像与深度选择、心电图门控31P磁共振波谱的联合研究。

Combined study of 1H-magnetic resonance imaging and depth-selected, EKG-gated 31P-magnetic resonance spectroscopy of the heart in vivo.

作者信息

Toyo-Oka T, Nagayama K, Umeda M, Ogawa S, Eguchi K, Hosoda S, Sugimoto T

出版信息

Biochem Biophys Res Commun. 1987 Apr 29;144(2):841-8. doi: 10.1016/s0006-291x(87)80041-4.

Abstract

NMR is useful for both 1H-magnetic resonance imaging (MRI) and magnetic resonance spectroscopy (MRS). We undertook to combine these two merits of NMR for in vivo characterization of living rat heart in wide bore (9 cm) superconducting magnet under high magnetic field (6.4 Tesla). Spatial resolution of 1H-MRI attained 0.1 mm by spin warp method. Then, depth-selected, EKG-gated 31P-MRS was performed, adjusting the detection area to cover the heart that was identified by the preceding 1H-MRI. Three evidences that 31P-SMR signal chiefly originated from the heart without cross talk of adjacent organs indicated that combination of 1H-MRI and in vivo 31P-MRS under high magnetic field in whole animal is promising for more accurate evaluation of cardiac muscle metabolism.

摘要

核磁共振（NMR）对氢-磁共振成像（MRI）和磁共振波谱学（MRS）均有用处。我们致力于将NMR的这两个优点结合起来，用于在高磁场（6.4特斯拉）下的大孔径（9厘米）超导磁体中对活体大鼠心脏进行体内特征描述。通过自旋扭曲法，氢-MRI的空间分辨率达到了0.1毫米。然后，进行深度选择、心电图门控的磷-31 MRS，将检测区域调整为覆盖由之前的氢-MRI识别出的心脏。磷-31 MRS信号主要源自心脏且无相邻器官串扰的三个证据表明，在全动物的高磁场下将氢-MRI与体内磷-31 MRS相结合，有望更准确地评估心肌代谢。