Xiamen Road Branch Hospital, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian 223002, China.
Dis Markers. 2022 Jun 28;2022:2083990. doi: 10.1155/2022/2083990. eCollection 2022.
Oxidative stress plays a key role in atherosclerosis. Acting via high level of reactive oxygen species, an increase of oxidative stress is involved in the pathogenesis and progression of atherosclerostic stenosis or occlusion of arteries. Oxidative stress leads to an accumulation of oxidized low-density lipoprotein, which plays important roles in steno-occlusion of cerebral and coronary arteries. However, the exact reasons for multiple cerebral and coronary artery steno-occlusion in elderly patients remain unclear. The aim was to evaluate the effects of imbalance of oxidative/antioxidative status on concomitant multiple brain infarcts and multiple chronic total coronary occlusions in elderly patients.
We measured the circulating levels of malondialdehyde (MDA), reactive oxygen species (ROS), thiobarbituric acid reactive substance (TBARS), advanced oxidation protein products (AOPP), superoxide dismutase 1 (SOD 1), superoxide dismutase 2 (SOD 2), superoxide dismutase 3 (SOD 3), and paraoxonase 1 (PON 1) in patients with concomitant multiple cerebral infarcts and multiple chronic total coronary occlusions.
Circulating levels of oxidative stress markers (MDA, ROS, TBARS, and AOPP) were increased ( < 0.001) and antioxidative stress markers (SOD 1, SOD 2, SOD 3, and PON 1) were decreased ( < 0.001) in elderly patients with concomitant multiple brain infarcts and multiple chronic total coronary occlusions.
The findings suggested that the imbalance of oxidative/antioxidative status may be associated with multiple cerebral infarcts and multiple chronic total coronary occlusions and may contribute to the development of concomitant multiple brain infarcts and multiple chronic total coronary occlusions in elderly patients.
氧化应激在动脉粥样硬化中起着关键作用。活性氧水平升高会导致氧化应激增加，从而参与动脉粥样硬化狭窄或闭塞的发病机制和进展。氧化应激导致氧化低密度脂蛋白的积累，在脑和冠状动脉狭窄或闭塞中发挥重要作用。然而，导致老年患者多发脑梗死和多发慢性完全性冠状动脉闭塞的确切原因仍不清楚。本研究旨在评估氧化/抗氧化状态失衡对老年患者同时发生多发性脑梗死和多发性慢性完全性冠状动脉闭塞的影响。
我们测量了同时患有多发性脑梗死和多发性慢性完全性冠状动脉闭塞的患者循环中丙二醛（MDA）、活性氧（ROS）、硫代巴比妥酸反应物质（TBARS）、晚期氧化蛋白产物（AOPP）、超氧化物歧化酶 1（SOD1）、超氧化物歧化酶 2（SOD2）、超氧化物歧化酶 3（SOD3）和对氧磷酶 1（PON1）的水平。
同时患有多发性脑梗死和多发性慢性完全性冠状动脉闭塞的老年患者循环中氧化应激标志物（MDA、ROS、TBARS 和 AOPP）水平升高（<0.001），抗氧化应激标志物（SOD1、SOD2、SOD3 和 PON1）水平降低（<0.001）。
这些发现表明，氧化/抗氧化状态失衡可能与多发性脑梗死和多发性慢性完全性冠状动脉闭塞有关，并可能导致老年患者同时发生多发性脑梗死和多发性慢性完全性冠状动脉闭塞。
