Karamouzos Vasileios, Paraskevas Themistoklis, Mulita Francesk, Karteri Sofia, Oikonomou Eleousa, Ntoulias Nikolaos, Pantzaris Nikolaos Dimitrios, Bourganou Vayanna, Velissaris Dimitrios
Intensive Care Unit, University Hospital of Patras, Patras, Greece.
Internal Medicine Department, University Hospital of Patras, Patras, Greece.
Mater Sociomed. 2022 Mar;34(1):33-36. doi: 10.5455/msm.2022.33.33-36.
Sepsis remains a major public health problem with increased incidence of mortality. As early recognition and prompt treatment in the first 'golden hour' remain the cornerstone of the septic patient approach, there is a real need for rapid and cost-effective reliable markers.
The aim of the study was to evaluate the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte percentage ratio (PL%R) in patients with sepsis who were initially treated in the Emergency Department and investigate their predictive ability regarding in-hospital mortality and performance comparing them to SOFA, APACHE II, and SAPS II score.
A retrospective observational study in the Emergency Department and Internal Medicine Department in a Mediterranean University Hospital. A total of forty-three patients suffering from sepsis were enrolled in the study. Demographic information, past medical history with pre-existing co-morbidities, physical examination findings, and radiological data were reviewed. Neutrophil to lymphocyte ratio and platelets to lymphocyte percentage ratio was calculated from the complete blood count (CBC). Disease severity was evaluated by calculating SOFA, SAPS II and APACHE II score on admission. The outcome of patients was noted as a primary endpoint.
Values of NLR and PL%R were statistically significantly higher in the group of non-survivors and correlate with sepsis prognostic scores.
Calculation of NLR and PL%R is easy, fast, and inexpensive in the assessment of patients with sepsis. Their role as prognostic indexes and their validity in the Emergency Department setting should be evaluated with large prospective studies.
脓毒症仍然是一个主要的公共卫生问题，死亡率不断上升。由于在首个“黄金小时”内的早期识别和及时治疗仍然是脓毒症患者治疗方法的基石，因此确实需要快速且经济高效的可靠标志物。
本研究的目的是评估在急诊科接受初始治疗的脓毒症患者的中性粒细胞与淋巴细胞比率（NLR）和血小板与淋巴细胞百分比比率（PL%R），并将它们与序贯器官衰竭评估（SOFA）、急性生理与慢性健康状况评分系统II（APACHE II）和简化急性生理学评分系统II（SAPS II）评分相比较，调查它们对院内死亡率的预测能力及其性能。
在一所地中海地区大学医院的急诊科和内科进行一项回顾性观察研究。共有43例脓毒症患者纳入本研究。回顾了人口统计学信息、既往病史及并存疾病、体格检查结果和放射学数据。根据全血细胞计数（CBC）计算中性粒细胞与淋巴细胞比率以及血小板与淋巴细胞百分比比率。入院时通过计算SOFA、SAPS II和APACHE II评分评估疾病严重程度。将患者的结局作为主要终点进行记录。
非存活组的NLR和PL%R值在统计学上显著更高，且与脓毒症预后评分相关。
在脓毒症患者评估中，计算NLR和PL%R简便、快速且成本低廉。它们作为预后指标的作用及其在急诊科环境中的有效性应通过大型前瞻性研究进行评估。
