Noroozian Maryam, Kormi-Nouri Reza, Nyberg Lars, Persson Jonas
Department of Psychiatry, School of Medicine, South Kargar Str., Tehran 13185/1741, Iran.
School of Law, Psychology and Social Work, Örebro University, Fakultetsgatan 1, Örebro 702 81, Sweden.
Cereb Cortex. 2023 Mar 10;33(6):3080-3097. doi: 10.1093/cercor/bhac262.
The neurobiological underpinnings of action-related episodic memory and how enactment contributes to efficient memory encoding are not well understood. We examine whether individual differences in level (n = 338) and 5-year change (n = 248) in the ability to benefit from motor involvement during memory encoding are related to gray matter (GM) volume, white matter (WM) integrity, and dopamine-regulating genes in a population-based cohort (age range = 25-80 years). A latent profile analysis identified 2 groups with similar performance on verbal encoding but with marked differences in the ability to benefit from motor involvement during memory encoding. Impaired ability to benefit from enactment was paired with smaller HC, parahippocampal, and putamen volume along with lower WM microstructure in the fornix. Individuals with reduced ability to benefit from encoding enactment over 5 years were characterized by reduced HC and motor cortex GM volume along with reduced WM microstructure in several WM tracts. Moreover, the proportion of catechol-O-methyltransferase-Val-carriers differed significantly between classes identified from the latent-profile analysis. These results provide converging evidence that individuals with low or declining ability to benefit from motor involvement during memory encoding are characterized by low and reduced GM volume in regions critical for memory and motor functions along with altered WM microstructure.
与动作相关的情景记忆的神经生物学基础以及动作执行如何促进有效的记忆编码尚未得到充分理解。我们研究了在基于人群的队列中（年龄范围 = 25 - 80岁），记忆编码过程中从运动参与中获益的能力在水平（n = 338）和5年变化（n = 248）方面的个体差异是否与灰质（GM）体积、白质（WM）完整性以及多巴胺调节基因有关。一项潜在剖面分析确定了两组在言语编码方面表现相似，但在记忆编码过程中从运动参与中获益的能力存在显著差异的人群。从动作执行中获益的能力受损与海马体、海马旁回和壳核体积较小以及穹窿中的白质微结构较低有关。在5年期间从编码动作执行中获益能力下降的个体，其特征是海马体和运动皮层的灰质体积减少，以及几个白质束中的白质微结构减少。此外，儿茶酚-O-甲基转移酶-Val携带者的比例在潜在剖面分析确定的类别之间存在显著差异。这些结果提供了一致的证据，表明在记忆编码过程中从运动参与中获益能力较低或下降的个体，其特征是对记忆和运动功能至关重要的区域的灰质体积较低且减少，同时白质微结构改变。
