• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

有和没有二尖瓣环分离的二尖瓣手术患者异质性队列的超声心动图描述及结果:一项卫生服务评估

Echocardiographic description and outcomes in a heterogeneous cohort of patients undergoing mitral valve surgery with and without mitral annular disjunction: a health service evaluation.

作者信息

Bennett Sadie, Tafuro Jacopo, Brumpton Marcus, Bardolia Caragh, Heatlie Grant, Duckett Simon, Ridley Paul, Nanjaiah Prakash, Kwok Chun Shing

机构信息

Heart and Lung Centre, University Hospitals of North Midlands, Stoke-on-Trent, ST4 6QG, UK.

Keele University, Stoke-on-Trent, UK.

出版信息

Echo Res Pract. 2022 Jul 13;9(1):4. doi: 10.1186/s44156-022-00004-7.

DOI:10.1186/s44156-022-00004-7
PMID:35821076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9277900/
Abstract

BACKGROUND

Mitral annular disjunction (MAD) is a structural abnormality characterized by the distinct separation of the mitral valve annulus/left atrium wall and myocardium. Little is known about the significance of MAD in patients requiring mitral valve surgery. This evaluation evaluates the echocardiographic characteristics and patient outcomes for patients with and without MAD who require mitral valve surgery.

METHODS

All patients who underwent mitral valve surgery and who had a pre-surgical transthoracic echocardiogram between 2013 and 2020 were included. Patient demographics and clinical outcomes were collected on review of patient electronic records.

RESULTS

A total of 185 patients were included in the analysis of which 32.4% had MAD (average MAD length 8.4 mm). MAD was seen most commonly in patients with mitral valve prolapse and myxomatous mitral valves disease (90% and 60% respectively). In the patients with MAD prior to mitral valve surgery, only 3.9% had MAD post mitral valve surgery. There were no significant difference in the severity of post-operative mitral regurgitation, arrhythmic events or major adverse cardiovascular events in patients with and without MAD.

CONCLUSIONS

MAD is common in patients who undergo mitral valve surgery. Current surgical techniques are able to correct the MAD abnormality in the vast majority of patients. MAD is not associated with an increased risk of adverse clinical outcomes post mitral valve surgery.

摘要

背景

二尖瓣环分离(MAD)是一种结构异常,其特征为二尖瓣环/左心房壁与心肌明显分离。对于需要进行二尖瓣手术的患者,MAD的意义鲜为人知。本评估旨在评价需要二尖瓣手术的有或无MAD患者的超声心动图特征及患者预后。

方法

纳入2013年至2020年间接受二尖瓣手术且术前有经胸超声心动图检查的所有患者。通过查阅患者电子记录收集患者人口统计学资料和临床结局。

结果

共有185例患者纳入分析,其中32.4%有MAD(平均MAD长度8.4毫米)。MAD最常见于二尖瓣脱垂和黏液瘤样二尖瓣疾病患者(分别为90%和60%)。在二尖瓣手术前有MAD的患者中,二尖瓣手术后仅有3.9%仍有MAD。有或无MAD的患者在术后二尖瓣反流严重程度、心律失常事件或主要不良心血管事件方面无显著差异。

结论

MAD在接受二尖瓣手术的患者中很常见。目前的手术技术能够在绝大多数患者中纠正MAD异常。MAD与二尖瓣手术后不良临床结局风险增加无关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e144/9277900/8b579463466a/44156_2022_4_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e144/9277900/dc4f6b090f47/44156_2022_4_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e144/9277900/8b579463466a/44156_2022_4_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e144/9277900/dc4f6b090f47/44156_2022_4_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e144/9277900/8b579463466a/44156_2022_4_Fig2_HTML.jpg

相似文献

1
Echocardiographic description and outcomes in a heterogeneous cohort of patients undergoing mitral valve surgery with and without mitral annular disjunction: a health service evaluation.有和没有二尖瓣环分离的二尖瓣手术患者异质性队列的超声心动图描述及结果:一项卫生服务评估
Echo Res Pract. 2022 Jul 13;9(1):4. doi: 10.1186/s44156-022-00004-7.
2
Mitral annular disjunction in surgical mitral valve prolapse: prevalence, characteristics and outcomes.外科二尖瓣脱垂中的二尖瓣环分离:患病率、特征及预后
Echo Res Pract. 2023 Nov 8;10(1):21. doi: 10.1186/s44156-023-00032-x.
3
Mitral annular disjunction in myxomatous mitral valve disease: a relevant abnormality recognizable by transthoracic echocardiography.黏液瘤样二尖瓣疾病中的二尖瓣环分离:一种经胸超声心动图可识别的相关异常。
Cardiovasc Ultrasound. 2010 Dec 9;8:53. doi: 10.1186/1476-7120-8-53.
4
The Mitral Annular Disjunction of Mitral Valve Prolapse: Presentation and Outcome.二尖瓣脱垂的二尖瓣环分离:表现与结局
JACC Cardiovasc Imaging. 2021 Nov;14(11):2073-2087. doi: 10.1016/j.jcmg.2021.04.029. Epub 2021 Jun 16.
5
Myxomatous Mitral Valve Disease with Mitral Valve Prolapse and Mitral Annular Disjunction: Clinical and Functional Significance of the Coincidence.伴有二尖瓣脱垂和二尖瓣环分离的黏液样二尖瓣疾病:两者并存的临床和功能意义
J Cardiovasc Dev Dis. 2021 Jan 24;8(2):9. doi: 10.3390/jcdd8020009.
6
Mitral annular disjunction: A systematic review of the literature.二尖瓣环分离:文献系统综述
Echocardiography. 2019 Aug;36(8):1549-1558. doi: 10.1111/echo.14437. Epub 2019 Aug 5.
7
Functional Implication of Mitral Annular Disjunction in Mitral Valve Prolapse: A Quantitative Dynamic 3D Echocardiographic Study.二尖瓣脱垂中瓣环分离的功能意义:一项定量动态 3D 超声心动图研究。
JACC Cardiovasc Imaging. 2017 Dec;10(12):1424-1433. doi: 10.1016/j.jcmg.2016.11.022. Epub 2017 May 17.
8
Mitral Annular Disjunction of Degenerative Mitral Regurgitation: Three-Dimensional Evaluation and Implications for Mitral Repair.退行性二尖瓣反流的二尖瓣环分离:三维评估及其对二尖瓣修复的意义。
J Am Soc Echocardiogr. 2022 Feb;35(2):165-175. doi: 10.1016/j.echo.2021.09.004. Epub 2021 Sep 10.
9
Mitral Annular Disjunction: Pathophysiology, Pro-Arrhythmic Profile and Repair Pearls.二尖瓣环分离:病理生理学、致心律失常特征及修复要点
Rev Cardiovasc Med. 2022 Mar 30;23(4):117. doi: 10.31083/j.rcm2304117. eCollection 2022 Apr.
10
Morphology of Mitral Annular Disjunction in Mitral Valve Prolapse.二尖瓣脱垂中二尖瓣环分离的形态学。
J Am Soc Echocardiogr. 2022 Feb;35(2):176-186. doi: 10.1016/j.echo.2021.09.002. Epub 2021 Sep 8.

引用本文的文献

1
Mitral annular disjunction and mitral valve prolapse: long-term risk of ventricular arrhythmias after surgery.二尖瓣环分离与二尖瓣脱垂:手术后室性心律失常的长期风险
Eur Heart J. 2025 Jul 21;46(28):2795-2805. doi: 10.1093/eurheartj/ehaf195.
2
Does Preliminary Chest Shape Assessment Improve the Prognostic Risk Stratification of Individuals with Mitral Annular Disjunction? A Case Report and Narrative Review.初步胸部形态评估能否改善二尖瓣环分离患者的预后风险分层?一例病例报告及文献综述
J Clin Med. 2025 Mar 26;14(7):2277. doi: 10.3390/jcm14072277.
3
The Prevalence, Pathophysiological Role and Determinants of Mitral Annular Disjunction Among Patients with Mitral Valve Prolapse: A Systematic Review.

本文引用的文献

1
The Mitral Annular Disjunction of Mitral Valve Prolapse: Presentation and Outcome.二尖瓣脱垂的二尖瓣环分离:表现与结局
JACC Cardiovasc Imaging. 2021 Nov;14(11):2073-2087. doi: 10.1016/j.jcmg.2021.04.029. Epub 2021 Jun 16.
2
Mitral annular disjunction in patients with severe aortic stenosis: Extent and reproducibility of measurements with computed tomography.重度主动脉瓣狭窄患者的二尖瓣环分离:计算机断层扫描测量的范围及可重复性
Eur J Radiol Open. 2021 Mar 9;8:100335. doi: 10.1016/j.ejro.2021.100335. eCollection 2021.
3
Prevalence and extent of mitral annular disjunction in structurally normal hearts: comprehensive 3D analysis using cardiac computed tomography.
二尖瓣脱垂患者二尖瓣环分离的患病率、病理生理作用及决定因素:一项系统评价
J Clin Med. 2025 Feb 20;14(5):1423. doi: 10.3390/jcm14051423.
4
Mitral annular disjunction in surgical mitral valve prolapse: prevalence, characteristics and outcomes.外科二尖瓣脱垂中的二尖瓣环分离:患病率、特征及预后
Echo Res Pract. 2023 Nov 8;10(1):21. doi: 10.1186/s44156-023-00032-x.
结构正常心脏中心脏二尖瓣环分离的流行率和程度:心脏计算机断层扫描的全面 3D 分析。
Eur Heart J Cardiovasc Imaging. 2021 May 10;22(6):614-622. doi: 10.1093/ehjci/jeab022.
4
Evolution from mitral annular dysfunction to severe mitral regurgitation in Barlow's disease.Barlow 病从二尖瓣环扩张到重度二尖瓣反流的演变。
Interact Cardiovasc Thorac Surg. 2021 Apr 19;32(4):506-514. doi: 10.1093/icvts/ivaa304.
5
A practical guideline for performing a comprehensive transthoracic echocardiogram in adults: the British Society of Echocardiography minimum dataset.成人经胸超声心动图全面检查实用指南:英国超声心动图学会最小数据集
Echo Res Pract. 2020 Dec;7(4):G59-G93. doi: 10.1530/ERP-20-0026.
6
Mitral annular disjunction in patients with primary severe mitral regurgitation and mitral valve prolapse.原发性重度二尖瓣反流和二尖瓣脱垂患者的二尖瓣环分离。
Echocardiography. 2020 Nov;37(11):1716-1722. doi: 10.1111/echo.14896. Epub 2020 Oct 22.
7
Parameters associated with ventricular arrhythmias in mitral valve prolapse with significant regurgitation.与二尖瓣脱垂伴大量反流相关的室性心律失常的参数。
Heart. 2021 Mar;107(5):411-418. doi: 10.1136/heartjnl-2020-317451. Epub 2020 Oct 1.
8
Multimodality imaging assessment of mitral annular disjunction in mitral valve prolapse.二尖瓣脱垂患者二尖瓣环分离的多模态影像学评估。
Heart. 2021 Jan;107(1):25-32. doi: 10.1136/heartjnl-2020-317330. Epub 2020 Jul 28.
9
Usefulness of 3-Tesla Cardiac Magnetic Resonance to Detect Mitral Annular Disjunction in Patients With Mitral Valve Prolapse.3.0T 心脏磁共振在检测二尖瓣脱垂患者二尖瓣瓣环分离中的应用。
Am J Cardiol. 2019 Dec 1;124(11):1725-1730. doi: 10.1016/j.amjcard.2019.08.047. Epub 2019 Sep 10.
10
Need for expertise in mitral valve regurgitation.二尖瓣反流专业知识的需求。
Open Heart. 2019 Apr 28;6(1):e001039. doi: 10.1136/openhrt-2019-001039. eCollection 2019.