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15 年来保加利亚患者中幽门螺杆菌对阿莫西林耐药性的增加。

Increase in amoxicillin resistance in Helicobacter pylori from Bulgarian patients over 15 years.

机构信息

Department of Medical Microbiology, Medical University of Sofia, Sofia, Bulgaria.

Department of General and Hepatobiliary Pancreatic Surgery, Department of Surgery, Medical University of Sofia, Sofia, Bulgaria.

出版信息

Diagn Microbiol Infect Dis. 2022 Sep;104(1):115746. doi: 10.1016/j.diagmicrobio.2022.115746. Epub 2022 Jun 17.

Abstract

Helicobacter pylori resistance to amoxicillin has usually been rare. We traced resistance evolution in 474 strains over 15 years. Although minimum inhibitory concentrations MIC and MIC were similar among subgroups, the overall resistance rate (MICs, >0.125-3 mg/L) significantly increased from 4.2% in 2007-2014 to 8.9% in 2015-2021.

摘要

幽门螺杆菌对阿莫西林的耐药性通常很少见。我们在 15 年内追踪了 474 株菌株的耐药性演变。尽管 MIC 和 MIC 在亚组之间相似,但总体耐药率(MICs,>0.125-3mg/L)从 2007-2014 年的 4.2%显著增加到 2015-2021 年的 8.9%。

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