妇科恶性肿瘤中 FAPI PET/CT 的进展及未来展望。
Advancement and Future Perspective of FAPI PET/CT In Gynecological Malignancies.
机构信息
Department of Nuclear Medicine, University Hospital Heidelberg, Germany; Department of Nuclear Medicine, Heinrich-Heine-University, Medical Faculty and University Hospital Duesseldorf, Duesseldorf Germany.
Department of Radiation Oncology, Heidelberg University Hospital, Germany; Department of Radiation Oncology, Heidelberg Institute of Radiation Oncology (HIRO), Germany; Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), Germany.
出版信息
Semin Nucl Med. 2022 Sep;52(5):628-634. doi: 10.1053/j.semnuclmed.2022.04.002. Epub 2022 Jul 13.
Fibroblast activation protein (FAP) is ubiquitously present in healthy tissue, and additionally upregulated by cancer associated fibroblasts (CAFs) leading to high levels of FAP. Thus, neoplastic tissue, which is containing CAFs, characterized by a high presence of FAP. Moreover, in more than 90% of all epithelial tumors this phenomenon seems to occur, including many gynecological tumors, providing the foundation for a successful application of FAP-ligands. However, FAP upregulation, can also be initiated by benign conditions such as inflammation, hormonal-influence, and wound healing. Gynecological cancers seem to represent a field of interest for the utilization of FAPI-PET/CT to potentially improve staging, restaging and therapeutic management. First highly promising investigations demand further research in order to validate these preliminary findings.
成纤维细胞激活蛋白（FAP）在健康组织中普遍存在，并且由癌相关成纤维细胞（CAFs）上调，导致 FAP 水平升高。因此，含有 CAFs 的肿瘤组织以 FAP 的高表达为特征。此外，这一现象似乎发生在超过 90%的所有上皮性肿瘤中，包括许多妇科肿瘤，为 FAP 配体的成功应用提供了基础。然而，FAP 的上调也可以由良性条件如炎症、激素影响和伤口愈合引发。妇科癌症似乎是利用 FAPI-PET/CT 来潜在改善分期、再分期和治疗管理的一个感兴趣的领域。首先，高度有前景的研究需要进一步的研究来验证这些初步发现。
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