College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China; State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.
State Key Joint Laboratory for Environmental Simulation and Pollution Control, College of Environmental Sciences and Engineering, Peking University, Beijing 100871, China.
Sci Total Environ. 2022 Nov 1;845:157379. doi: 10.1016/j.scitotenv.2022.157379. Epub 2022 Jul 14.
Methylsiloxanes (MSs) are widely used as solvents or emollients in various personal care products (PCPs) and may pose a health risk. In this study, we assessed external and internal exposure to MSs among students at two universities in southwestern China. Samples of air, dust, and PCPs were collected to evaluate indoor non-dietary exposure to MSs via multiple pathways among the students. Indoor MS levels were approximately 1-3 orders of magnitude higher in the dormitories of female students than in either classrooms or the dormitories of male students. Lipstick contained the highest MS levels. Cyclic MS (CMS: D4-D6) levels were 1 order of magnitude higher in female students than in male students. Among the three CMSs, D5 levels were highest in the plasma of all students (1.3-15 ng/mL). In dormitories, dermal contact with PCPs was the major route of exposure to CMSs for all students. Among linear MSs (LMSs: L5-L16), dermal PCP absorption and dust ingestion were the predominant exposure routes for male and female students, respectively. Although the overall risk of exposure to D4 and D5 was below the chronic reference dose for all exposure routes and all students, the total daily doses of exposure to D4 and D5 via dermal PCP absorption approached the chronic reference dose in four female students. Therefore, the effects of MSs on female students should be further investigated in future studies.
硅氧烷（MSs）作为溶剂或润肤剂广泛应用于各种个人护理产品（PCPs）中，可能对健康构成风险。在这项研究中，我们评估了中国西南部两所大学学生的外部和内部 MSs 暴露情况。收集了空气、灰尘和 PCPs 样本，以评估学生通过多种途径经室内非饮食途径摄入 MSs 的情况。女生宿舍内 MS 水平大约比男生的教室或宿舍高 1-3 个数量级。口红中 MS 含量最高。与男生相比，女生的环状 MS（CMS：D4-D6）水平高 1 个数量级。在所有学生中，三种 CMS 中 D5 在血浆中的含量最高（1.3-15ng/ml）。在宿舍内，所有学生通过与 PCPs 的皮肤接触是接触 CMSs 的主要途径。对于线性 MSs（LMSs：L5-L16），皮肤 PCP 吸收和灰尘摄入是男生和女生的主要暴露途径。尽管通过所有暴露途径和所有学生的慢性参考剂量，D4 和 D5 的总暴露风险较低，但四名女生通过皮肤 PCP 吸收接触 D4 和 D5 的每日总剂量接近慢性参考剂量。因此，在未来的研究中应进一步调查 MSs 对女生的影响。
