From the Department of Neurology (C.T.P., A.E.H.), Johns Hopkins University School of Medicine, Baltimore, MD; Department of Neurosurgery (M.L.), Barrow Neurological Institute, Phoenix, AZ; and The Russell H. Morgan Department of Radiology and Radiological Sciences (F.K.H.), Johns Hopkins Hospital, Baltimore, MD.
Neurology. 2022 Sep 27;99(13):577-580. doi: 10.1212/WNL.0000000000201037. Epub 2022 Jul 18.
Cognitive dysfunction is often multifaceted and can be seen across all age groups in medicine. The combination of cognitive decline and increased intracranial pressure may suggest possible anatomical abnormalities. We present a case report from our academic center that describes a young man with new cognitive fatigue and brain fog in the setting of increased venous pressure that resolved with surgical intervention at a site of jugular vein stenosis. We discuss current hypotheses from basic and clinical research related to pathophysiology underlying venous vascular congestion and associated neurologic disorders. Further research is warranted to elucidate the underlying mechanisms of venous congestion and cognition to better identify therapies and improve quality of life for patients.
认知功能障碍通常是多方面的,在医学上可以在所有年龄段看到。认知能力下降和颅内压增高的结合可能提示可能存在解剖异常。我们从我们的学术中心报告了一个病例,描述了一名年轻男性在静脉压升高的情况下出现新的认知疲劳和脑雾,在颈静脉狭窄部位进行手术干预后得到缓解。我们讨论了基础和临床研究中与静脉血管充血和相关神经障碍相关的病理生理学的当前假说。需要进一步的研究来阐明静脉充血和认知的潜在机制,以更好地确定治疗方法并提高患者的生活质量。