在使用度伐鲁单抗时，类圆线虫——一种导致嗜酸性粒细胞增多症的不常见病因。
Strongyloides-An uncommon cause of eosinophilia whilst on durvalumab.
机构信息
Department of Medical Oncology, Calvary Mater Newcastle, Waratah, Australia.
Department of Infectious Diseases, Calvary Mater Newcastle, Waratah, Australia.
出版信息
Cancer Rep (Hoboken). 2022 Oct;5(10):e1682. doi: 10.1002/cnr2.1682. Epub 2022 Jul 18.
BACKGROUND
In malignancy, eosinophils have been shown to play an important role in the tumour micro-environment. Increasingly, development of eosinophilia with immune checkpoint inhibitor (ICI) use is thought to be predictive of prognosis and development of immune-related adverse events. However, there are many other causes for developing eosinophilia which can contribute to the difficulties in diagnosis and management.
CASE
Here, we present a case of Strongyloides parasitic infection as an uncommon differential for eosinophilia in a patient with lung cancer receiving a PDL-1 ICI, durvalumab, in Australia.
CONCLUSION
This case highlights the complexities exploring the multiple potential causes of eosinophilia and the subsequent management, to allow safe continuation of ICI.
背景
在恶性肿瘤中，嗜酸性粒细胞已被证明在肿瘤微环境中发挥重要作用。越来越多的证据表明，免疫检查点抑制剂（ICI）使用后嗜酸性粒细胞增多与预后和免疫相关不良事件的发生有关。然而，嗜酸性粒细胞增多还有许多其他原因，这给诊断和治疗带来了困难。
病例
在这里，我们报告了一例澳大利亚肺癌患者在接受 PD-1 ICI 药物度伐鲁单抗治疗时，因寄生虫感染导致的嗜酸性粒细胞增多的不常见鉴别病例。
结论
本病例强调了探索嗜酸性粒细胞增多的多种潜在原因及其后续管理的复杂性，以确保 ICI 的安全使用。
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