Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, the Center for Women's Reproductive Health, the Division of Infectious Diseases, Department of Medicine, the Division of Neonatology, Department of Pediatrics, the Department of Biostatistics, School of Public Health, and the Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.
Obstet Gynecol. 2022 Aug 1;140(2):262-265. doi: 10.1097/AOG.0000000000004849. Epub 2022 May 18.
Two years into the coronavirus disease 2019 (COVID-19) pandemic, we have now seen three main variant waves. We performed a retrospective cohort study of all pregnant patients with COVID-19 at our institution from March 22, 2020, to February 26, 2022, to evaluate disease severity and perinatal outcomes among the variants. Patients were categorized as pre-Delta (March 22, 2020-May 31, 2021), Delta (July 1, 2021-December 15, 2021), or Omicron (December 16, 2021- February 26, 2022) based on variant tracking from the Centers for Disease Control and Prevention and genotype sequencing at our institution. There were fewer cases of severe-critical disease (1.8% Omicron vs 13.3% pre-Delta and 24.1% Delta) and adverse perinatal outcomes during the Omicron wave compared with the pre-Delta and Delta waves.
在 2019 冠状病毒病（COVID-19）大流行的两年后，我们现在已经看到了三波主要的变异浪潮。我们对 2020 年 3 月 22 日至 2022 年 2 月 26 日期间我院所有 COVID-19 孕妇患者进行了回顾性队列研究，以评估变异株之间的疾病严重程度和围产期结局。根据美国疾病控制与预防中心的变异追踪和我院的基因分型测序，患者被分为德尔塔前（2020 年 3 月 22 日至 2021 年 5 月 31 日）、德尔塔（2021 年 7 月 1 日至 2021 年 12 月 15 日）或奥密克戎（2021 年 12 月 16 日至 2022 年 2 月 26 日）。与德尔塔波相比，奥密克戎波期间严重/危重症病例（1.8%奥密克戎 vs 13.3%德尔塔前和 24.1%德尔塔）和不良围产结局较少。
