1,3-二硫戊环-2-酮的汇聚合成方法及内酯的意外合成。
A Convergent Approach to 1,3-Dithiolan-2-ones and an Unexpected Synthesis of Lactones.
机构信息
Laboratoire de Synthèse Organique, CNRS UMR 7652 Ecole Polytechnique, 91128 Palaiseau, Cedex, France.
出版信息
Org Lett. 2022 Jul 29;24(29):5245-5248. doi: 10.1021/acs.orglett.2c02215. Epub 2022 Jul 21.
PMID:35861650
Abstract
A convergent route to 1,3-dithiolan-2-ones based on the radical addition of xanthates to allylic acetates is described. The process is modular, uses inexpensive starting materials and reagents, and is atom economical, since both sulfur atoms of the xanthate end up in the products. With adducts derived from xanthates bearing an ester group, an unexpected transformation leading to lactones was uncovered.
摘要
本文描述了一种基于黄原酸酯自由基加成到烯丙基乙酸酯的 1,3-二硫杂环戊-2-酮的汇聚路线。该过程具有模块化、使用廉价的起始原料和试剂以及原子经济性，因为黄原酸酯的两个硫原子最终都存在于产物中。对于带有酯基的黄原酸酯衍生的加成物，发现了一种导致内酯的意外转化。
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