Ehrich J H, Rothgänger S
Klin Padiatr. 1987 Mar-Apr;199(2):98-102. doi: 10.1055/s-2008-1026771.
Cholinesterase activity and concentrations of total protein, albumin and globulins were measured in the serum of 94 carefully selected prematures and newborns during the first week of life. Cholinesterase activity was significantly lower in prematures than in newborns. There was a weak correlation between serum concentration of albumin and cholinesterase activity. Total protein, albumin and gamma-globulins were significantly lower in premature babies. With the exception of alpha-1-globulin, all proteins correlated positively with gestational age. There was no difference in total serum protein concentration between small for gestational age infants and appropriate for gestational age infants. Postnatally, serum protein and cholinesterase activity rose by 27 44% within 7 to 10 weeks in prematures of 30-33 weeks of gestational age. A single infusion of 0.5 g/kg b.w. albumin transiently increased the protein concentration of prematures 1.5 fold; 7 to 10 weeks later, protein concentrations of treated and untreated prematures were no longer different. In conclusion, cholinesterase activity and protein concentrations correlated with gestational age. In prematures with disturbed microcirculation, albumin infusions resulted in a transient increase of protein concentration.
在94名精心挑选的早产儿和新生儿出生后第一周的血清中，检测了胆碱酯酶活性以及总蛋白、白蛋白和球蛋白的浓度。早产儿的胆碱酯酶活性显著低于新生儿。血清白蛋白浓度与胆碱酯酶活性之间存在微弱的相关性。早产儿的总蛋白、白蛋白和γ-球蛋白显著较低。除α-1球蛋白外，所有蛋白质均与胎龄呈正相关。小于胎龄儿和适于胎龄儿的血清总蛋白浓度没有差异。出生后，孕龄30 - 33周的早产儿在7至10周内血清蛋白和胆碱酯酶活性升高了27%至44%。单次输注0.5 g/kg体重的白蛋白可使早产儿的蛋白浓度短暂增加1.5倍；7至10周后，治疗组和未治疗组早产儿的蛋白浓度不再有差异。总之，胆碱酯酶活性和蛋白浓度与胎龄相关。在微循环紊乱的早产儿中，输注白蛋白会导致蛋白浓度短暂升高。
