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胎儿镜下腔内气管闭塞术治疗先天性膈疝的细胞和分子效应

The Cellular and Molecular Effects of Fetoscopic Endoluminal Tracheal Occlusion in Congenital Diaphragmatic Hernia.

作者信息

Olutoye Ii Oluyinka O, Short Walker D, Gilley Jamie, Hammond Ii J D, Belfort Michael A, Lee Timothy C, King Alice, Espinoza Jimmy, Joyeux Luc, Lingappan Krithika, Gleghorn Jason P, Keswani Sundeep G

机构信息

Division of Pediatric Surgery, Department of Surgery, Texas Children's Hospital, Houston, TX, United States.

Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, United States.

出版信息

Front Pediatr. 2022 Jul 5;10:925106. doi: 10.3389/fped.2022.925106. eCollection 2022.

DOI:10.3389/fped.2022.925106
PMID:35865706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9294219/
Abstract

Congenital diaphragmatic hernia (CDH) is a complex disease associated with pulmonary hypoplasia and pulmonary hypertension. Great strides have been made in our ability to care for CDH patients, specifically in the prenatal improvement of lung volume and morphology with fetoscopic endoluminal tracheal occlusion (FETO). While the anatomic effects of FETO have been described in-depth, the changes it induces at the cellular and molecular level remain a budding area of CDH research. This review will delve into the cellular and molecular effects of FETO in the developing lung, emphasize areas in which further research may improve our understanding of CDH, and highlight opportunities to optimize the FETO procedure for improved postnatal outcomes.

摘要

先天性膈疝（CDH）是一种与肺发育不全和肺动脉高压相关的复杂疾病。我们在照顾CDH患者的能力方面取得了巨大进展，特别是在产前通过胎儿镜腔内气管闭塞术（FETO）改善肺容量和形态方面。虽然FETO的解剖学效应已得到深入描述，但其在细胞和分子水平上引起的变化仍是CDH研究的一个新兴领域。本综述将深入探讨FETO对发育中肺的细胞和分子效应，强调进一步研究可能增进我们对CDH理解的领域，并突出优化FETO手术以改善产后结局的机会。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/a0cad2087d82/fped-10-925106-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/4253282a2a5b/fped-10-925106-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/05c741242f74/fped-10-925106-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/24d6c6dece97/fped-10-925106-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/a0cad2087d82/fped-10-925106-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/4253282a2a5b/fped-10-925106-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/05c741242f74/fped-10-925106-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/24d6c6dece97/fped-10-925106-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/99e0/9294219/a0cad2087d82/fped-10-925106-g0004.jpg

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Pulm Circ. 2021 Oct 21;11(4):20458940211046137. doi: 10.1177/20458940211046137. eCollection 2021 Oct-Dec.
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