Division of Experimental Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada.
Division of General Surgery, Department of Surgery, McGill University, Montreal, QC, Canada.
Front Immunol. 2022 Jul 7;13:903913. doi: 10.3389/fimmu.2022.903913. eCollection 2022.
Tumor necrosis factor receptor 2 (TNFR2) has been shown to play a crucial role in CD4+ T regulatory cells (CD4+Tregs) expansion and suppressive function. Increasing evidence has also demonstrated its role in a variety of immune regulatory cell subtypes such as CD8+ T regulatory cells (CD8+ Tregs), B regulatory cells (Bregs), and myeloid-derived suppressor cells (MDSCs). In solid organ transplantation, regulatory immune cells have been associated with decreased ischemia-reperfusion injury (IRI), improved graft survival, and improved overall outcomes. However, despite TNFR2 being studied in the context of autoimmune diseases, cancer, and hematopoietic stem cell transplantation, there remains paucity of data in the context of solid organ transplantation and islet cell transplantation. Interestingly, TNFR2 signaling has found a clinical application in islet transplantation which could guide its wider use. This article reviews the current literature on TNFR2 expression in immune modulatory cells as well as IRI, cell, and solid organ transplantation. Our results highlighted the positive impact of TNFR2 signaling especially in kidney and islet transplantation. However, further investigation of TNFR2 in all types of solid organ transplantation are required as well as dedicated studies on its therapeutic use during induction therapy or treatment of rejection.
肿瘤坏死因子受体 2（TNFR2）在 CD4+T 调节性细胞（CD4+Tregs）的扩增和抑制功能中起着至关重要的作用。越来越多的证据表明，它在各种免疫调节细胞亚型中也发挥着作用，如 CD8+T 调节性细胞（CD8+Tregs）、B 调节性细胞（Bregs）和髓系来源的抑制细胞（MDSCs）。在实体器官移植中，调节性免疫细胞与减少缺血再灌注损伤（IRI）、改善移植物存活和改善整体预后有关。然而，尽管 TNFR2 在自身免疫性疾病、癌症和造血干细胞移植的背景下进行了研究，但在实体器官移植和胰岛细胞移植的背景下，数据仍然很少。有趣的是，TNFR2 信号在胰岛移植中找到了临床应用，这可能会指导其更广泛的应用。本文综述了 TNFR2 在免疫调节细胞以及 IRI、细胞和实体器官移植中的表达的最新文献。我们的结果强调了 TNFR2 信号的积极影响，特别是在肾和胰岛移植中。然而，需要对所有类型的实体器官移植中的 TNFR2 进行进一步研究，并对其在诱导治疗或排斥治疗期间的治疗用途进行专门研究。
