Jin Chaoyang, Yang Lei, Qi Shouliang, Teng Yueyang, Li Chen, Yao Yudong, Ruan Xiuhang, Wei Xinhua
College of Medicine and Biological Information Engineering, Northeastern University, Shenyang, China.
Key Laboratory of Intelligent Computing in Medical Image, Ministry of Education, Northeastern University, Shenyang, China.
Front Aging Neurosci. 2022 Jul 8;14:944925. doi: 10.3389/fnagi.2022.944925. eCollection 2022.
Diffusion tensor imaging (DTI) studies have investigated white matter (WM) integrity abnormalities in Parkinson's disease (PD). However, little is known about the topological changes in the brain network. This study aims to reveal these changes by comparing PD without freezing of gait (FOG) (PD FOG-), PD with FOG (PD FOG+), and healthy control (HC).
21 PD FOG+, 34 PD FOG-, and 23 HC were recruited, and DTI images were acquired. The graph theoretical analysis and network-based statistical method were used to calculate the topological parameters and assess connections.
PD FOG+ showed a decreased normalized clustering coefficient, small-worldness, clustering coefficient, and increased local network efficiency compared with HCs. PD FOG+ showed decreased centrality, degree centrality, and nodal efficiency in the striatum, frontal gyrus, and supplementary motor area (SMA). PD FOG+ showed decreased connections in the frontal gyrus, cingulate gyrus, and caudate nucleus (CAU). The between centrality of the left SMA and left CAU was negatively correlated with FOG questionnaire scores.
This study demonstrates that PD FOG+ exhibits disruption of global and local topological organization in structural brain networks, and the disrupted topological organization can be potential biomarkers in PD FOG+. These new findings may provide increasing insight into the pathophysiological mechanism of PD FOG+.
扩散张量成像(DTI)研究已对帕金森病(PD)中的白质(WM)完整性异常进行了调查。然而,关于脑网络的拓扑变化却知之甚少。本研究旨在通过比较无冻结步态(FOG)的PD(PD FOG-)、有FOG的PD(PD FOG+)和健康对照(HC)来揭示这些变化。
招募了21名PD FOG+、34名PD FOG-和23名HC,并采集了DTI图像。采用图论分析和基于网络的统计方法来计算拓扑参数并评估连接性。
与HC相比,PD FOG+的标准化聚类系数、小世界性质、聚类系数降低,局部网络效率增加。PD FOG+在纹状体、额回和辅助运动区(SMA)的中心性、度中心性和节点效率降低。PD FOG+在额回、扣带回和尾状核(CAU)的连接减少。左侧SMA和左侧CAU之间的中介中心性与FOG问卷评分呈负相关。
本研究表明,PD FOG+在大脑结构网络中表现出全局和局部拓扑组织的破坏,而这种破坏的拓扑组织可能是PD FOG+的潜在生物标志物。这些新发现可能会为PD FOG+的病理生理机制提供更多的见解。