Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Shahid Hemmat Exp. way, Tehran, Iran.
Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, Iran.
Exp Brain Res. 2022 Sep;240(9):2311-2326. doi: 10.1007/s00221-022-06425-4. Epub 2022 Jul 25.
The evidence for the hemispheric specialization of motor planning reveals several inconsistencies between the left-lateralized hypothesis and a distributed system across the hemispheres. We compared participants with left hemiplegic cerebral palsy (HCP) to right-handed control subjects in this study's first experiment by inviting them to perform a motor planning task. Participants were required to release the start button, grasp a hexagon, and rotate it according to the instructions. In the second experiment, we compared left-HCP subjects with right-HCP subjects inviting them to perform the same task (we used the data for left-HCP subjects from the first experiment). P2 amplitude, as well as planning time, grasping time, releasing time, and initial grip selection planning patterns, were used as outcome measures in both experiments. The first experiment revealed that controls acted more quickly and chose more effective planning patterns. Also, the P2 amplitude was smaller in left-HCP subjects than in control subjects. No significant group effect was observed in the second experiment for any movement-related measure or P2. At the neural level, however, there was an interaction between 'region' and 'group,' indicating the distinction between the two groups in the right region. The results are discussed in terms of motor planning's hemispheric distribution and individual differences in the HCP group.
运动规划的半球专门化证据揭示了左侧假说和半球间分布式系统之间的几个不一致之处。在这项研究的第一个实验中，我们通过邀请参与者执行运动规划任务，将左偏瘫脑瘫（HCP）患者与右利手对照组进行了比较。参与者被要求释放开始按钮，抓住一个六边形，并按照指示旋转它。在第二个实验中，我们比较了左 HCP 受试者和右 HCP 受试者，邀请他们执行相同的任务（我们使用第一个实验中左 HCP 受试者的数据）。P2 幅度以及规划时间、抓取时间、释放时间和初始抓握选择规划模式被用作两个实验的结果测量。第一个实验表明，对照组的动作更快，选择了更有效的规划模式。此外，左 HCP 受试者的 P2 幅度小于对照组。第二个实验中，任何与运动相关的测量或 P2 都没有观察到显著的组间效应。然而，在神经水平上，“区域”和“组”之间存在交互作用，表明右区域两组之间存在差异。结果根据 HCP 组运动规划的半球分布和个体差异进行了讨论。
