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经导管主动脉瓣植入术的生物力学

Biomechanics of Transcatheter Aortic Valve Implant.

作者信息

Nappi Francesco, Avtaar Singh Sanjeet Singh, Nappi Pierluigi, Fiore Antonio

机构信息

Department of Cardiac Surgery, Centre Cardiologique du Nord, 93200 Saint-Denis, France.

Department of Cardiothoracic Surgery, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK.

出版信息

Bioengineering (Basel). 2022 Jul 4;9(7):299. doi: 10.3390/bioengineering9070299.

Abstract

Transcatheter aortic valve implantation (TAVI) has grown exponentially within the cardiology and cardiac surgical spheres. It has now become a routine approach for treating aortic stenosis. Several concerns have been raised about TAVI in comparison to conventional surgical aortic valve replacement (SAVR). The primary concerns regard the longevity of the valves. Several factors have been identified which may predict poor outcomes following TAVI. To this end, the lesser-used finite element analysis (FEA) was used to quantify the properties of calcifications which affect TAVI valves. This method can also be used in conjunction with other integrated software to ascertain the functionality of these valves. Other imaging modalities such as multi-detector row computed tomography (MDCT) are now widely available, which can accurately size aortic valve annuli. This may help reduce the incidence of paravalvular leaks and regurgitation which may necessitate further intervention. Structural valve degeneration (SVD) remains a key factor, with varying results from current studies. The true incidence of SVD in TAVI compared to SAVR remains unclear due to the lack of long-term data. It is now widely accepted that both are part of the armamentarium and are not mutually exclusive. Decision making in terms of appropriate interventions should be undertaken via shared decision making involving heart teams.

摘要

经导管主动脉瓣植入术(TAVI)在心脏病学和心脏外科领域呈指数级增长。如今,它已成为治疗主动脉瓣狭窄的常规方法。与传统外科主动脉瓣置换术(SAVR)相比,TAVI引发了一些担忧。主要担忧涉及瓣膜的使用寿命。已经确定了几个可能预测TAVI术后不良结局的因素。为此,较少使用的有限元分析(FEA)被用于量化影响TAVI瓣膜的钙化特性。该方法还可与其他集成软件结合使用,以确定这些瓣膜的功能。现在,其他成像方式如多排探测器计算机断层扫描(MDCT)已广泛应用,其可准确测量主动脉瓣环大小。这可能有助于降低瓣周漏和反流的发生率,而瓣周漏和反流可能需要进一步干预。结构性瓣膜退变(SVD)仍然是一个关键因素,目前的研究结果各不相同。由于缺乏长期数据,TAVI与SAVR相比SVD的真实发生率仍不清楚。现在人们普遍认为,两者都是治疗手段的一部分,并非相互排斥。应通过心脏团队参与的共同决策来进行适当干预的决策。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c3c5/9312295/7b518036b5ef/bioengineering-09-00299-g001.jpg

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