聚苯乙烯微塑料对雄性大鼠生殖参数的慢性毒性作用。
Chronic toxic effects of polystyrene microplastics on reproductive parameters of male rats.
作者信息
Ilechukwu Ifenna, Ehigiator Ben Enoluomen, Ben Inemesit Okon, Okonkwo Chinedu Joseph, Olorunfemi Oluwakemi S, Modo Uchechukwu Emmanuel, Ilechukwu Chibuamam Ezinwanneamaka, Ohagwa Ngozika Juliet
机构信息
Graduate School of Engineering and Science, Department of Marine and Environmental Science, University of the Ryukyus, Nishihara, Okinawa, Japan.
Environmental Chemistry Unit, Department of Industrial Chemistry, Madonna University, Elele Campus, Rivers State, Nigeria.
出版信息
Environ Anal Health Toxicol. 2022 Jun;37(2):e2022015-0. doi: 10.5620/eaht.2022015. Epub 2022 Jun 15.
Microplastics have become a significant environmental concern. However, information on toxicity of microplastics in terrestrial organisms is limited. In this study, the chronic toxic effects of polystyrene microplastics (PS-MPs) on the reproductive system and serum antioxidants of male albino Wistar rats fed for 90 days with standard rat feed containing 1-10% granules of crushed polystyrene disposable plates were evaluated. Significant reductions in volume, motility, epididymal sperm count and serum testosterone level were observed. Histological examination of testicular architecture showed distorted testes with vacuolated seminiferous tubules at the highest percentage, together with increased catalase and decreased superoxide dismutase activities. This study showed that ingestion of PS-MPs caused reproductive dysfunction in male rats and contributes to understanding the potential toxicity of microplastics in terrestrial animals.
微塑料已成为一个重大的环境问题。然而，关于微塑料对陆生生物毒性的信息有限。在本研究中，评估了聚苯乙烯微塑料（PS-MPs）对雄性白化Wistar大鼠生殖系统和血清抗氧化剂的慢性毒性作用，这些大鼠用含有1-10%粉碎聚苯乙烯一次性盘子颗粒的标准大鼠饲料喂养90天。观察到体积、活力、附睾精子数量和血清睾酮水平显著降低。睾丸结构的组织学检查显示，睾丸扭曲，曲细精管空泡化的比例最高，同时过氧化氢酶活性增加，超氧化物歧化酶活性降低。本研究表明，摄入PS-MPs会导致雄性大鼠生殖功能障碍，并有助于了解微塑料对陆生动物的潜在毒性。
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