Tschaidse Lea, Auer Matthias K, Dubinski Ilja, Lottspeich Christian, Nowotny Hanna, Schmidt Heinrich, Gut Nadezda, Reisch Nicole
Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, 80336 Munich, Germany.
Department of Pediatric Endocrinology, Dr. von Haunersches Children's Hospital, Klinikum der Universität München, LMU München, 80336 Munich, Germany.
J Clin Med. 2022 Jul 25;11(15):4307. doi: 10.3390/jcm11154307.
The occurrence of ectopic prostate tissue in the female genital tract is rare and has only been described sporadically. The origin of these lesions is unclear, but their appearance seems to be associated with various forms of androgen excess, including androgen therapy for transgender treatment or disorders of sex development, such as classic congenital adrenal hyperplasia (CAH). This is the first described case of ectopic prostate tissue in the cervix uteri of a 46,XX patient with a confirmed diagnosis of non-classic CAH due to 21-OHD and a history of mild adrenal androgen excess.
We describe a 34-year-old patient with a genetic diagnosis of non-classic CAH due to 21-hydroxylase deficiency (21-OHD) with a female karyo- and phenotype and a history of mild adrenal androgen excess. Due to dysplasia in the cervical smear, conization had to be performed, revealing ectopic prostate tissue in the cervix uteri of the patient.
An association between androgen excess and the occurrence of prostate tissue is likely and should therefore be considered as a differential diagnosis for atypical tissue in the female genital tract.
女性生殖道中异位前列腺组织的发生极为罕见，仅有零星报道。这些病变的起源尚不清楚，但其出现似乎与各种形式的雄激素过多有关，包括用于跨性别治疗的雄激素疗法或性发育障碍，如经典型先天性肾上腺皮质增生症（CAH）。这是首例在一名46,XX患者的子宫颈中发现异位前列腺组织的病例，该患者确诊为因21-羟化酶缺乏（21-OHD）导致的非经典型CAH，并有轻度肾上腺雄激素过多的病史。
我们描述了一名34岁患者，基因诊断为因21-羟化酶缺乏（21-OHD）导致的非经典型CAH，具有女性核型和表型，并有轻度肾上腺雄激素过多的病史。由于宫颈涂片显示发育异常，不得不进行锥切术，结果在患者的子宫颈中发现了异位前列腺组织。
雄激素过多与前列腺组织的出现之间可能存在关联，因此应将其视为女性生殖道非典型组织的鉴别诊断之一。
