Gynecology and Obstetrics Clinic, University Clinical Center Niš, Serbia.
Faculty of Medicine, University of Niš, Serbia.
Ginekol Pol. 2023;94(4):283-290. doi: 10.5603/GP.a2022.0038. Epub 2022 Jul 27.
To establish whether there is a statistically significant difference in hematological and biochemical parameters between the patients with premalignant changes of the uterine mucosa and those with malignant changes. The aim is to establish whether hematological and biochemical parameters may be useful in predicting the stages of endometrial malignancy and in differentiating premalignant and malignant endometrial changes.
A retrospective study included 100 patients (70 with endometrial carcinoma diagnosis and 30 with atypical hyperplasia). We compared hematological and biochemical parameters in both groups.
CRP, granulocytes, platelets, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) are statistically significantly higher in patients with malignant changes. Lymphocyte count is statistically significantly lower in patients with malignant changes. Platelet count is statistically significantly lower in patients with stages I and II in comparison to patients with higher disease stage. NLR and PLR have good discriminatory power for carcinoma presence. Patients with advanced changes have statistically significantly higher CRP values, higher granulocyte and platelet count, as well as higher values of NLR and PLR, and statistically significantly lower values of lymphocytes and MPV in comparison to benign changes.
There is a possibility of using hematological and biochemical parameters in the assessment of endometrial changes as well as in the prediction of stages, in confirmed malignant changes of the endometrium.
确定具有子宫黏膜癌前病变和恶性病变的患者之间在血液学和生化参数方面是否存在统计学显著差异。目的是确定血液学和生化参数是否可用于预测子宫内膜恶性程度分期，并区分癌前病变和恶性子宫内膜病变。
回顾性研究纳入了 100 名患者（70 名子宫内膜癌诊断患者和 30 名非典型增生患者）。我们比较了两组患者的血液学和生化参数。
CRP、粒细胞、血小板、中性粒细胞-淋巴细胞比值（NLR）和血小板-淋巴细胞比值（PLR）在恶性病变患者中显著升高。恶性病变患者的淋巴细胞计数显著降低。与疾病分期较高的患者相比，I 期和 II 期患者的血小板计数显著降低。NLR 和 PLR 对癌存在具有良好的鉴别能力。与良性病变相比，进展性病变患者的 CRP 值、粒细胞和血小板计数更高，NLR 和 PLR 值更高，淋巴细胞和MPV 值更低。
在评估子宫内膜变化以及预测子宫内膜恶性病变的分期方面，血液学和生化参数具有一定的应用价值。
