Silva Lea Barbetta Pereira da, Mercês de Jesus Gilmar, Bessa Junior José de, Silva Valter Abrantes Pereira da, Mattos Ivanilde Guedes de, Jenerette Coretta Melissa, Carvalho Evanilda Souza de Santana
Department of Health, Universidade Estadual de Feira de Santana, Feira de Santana, BA,Brazil.
Department of Education, Universidade do Estado da Bahia, Alagoinhas, BA,Brazil.
Pediatr Exerc Sci. 2022 Jul 22;35(2):84-91. doi: 10.1123/pes.2021-0188. Print 2023 May 1.
Sickle cell disease is the most common genetic hemoglobinopathy globally and systemically affects body functioning, decreasing exercise capacity.
To assess exercise capacity through the 6-minute walk test (6MWT) and biomarkers in children and adolescents with sickle cell disease.
Cross-sectional study involving 20 children and adolescents from Brazil. Demographic and socioeconomic data were obtained. Baseline measurements included biomarkers (red blood cells, hemoglobin, hematocrit, white blood cells, platelets, reticulocytes, lactate dehydrogenase, creatine phosphokinase, C-reactive protein, interleukin 6, and fetal hemoglobin). The following data were obtained before, during, and after the 6MWT: heart rate, blood pressure, and peripheral oxygen saturation.
Eighteen children and adolescents ages 5-14 years old were analyzed, 61.1% boys, 100% black or brown, and 61.1% in primary education, with low household income. The average distance walked in 6MWT was 463.8 (137.7) m, significantly less than the predicted value (P < .001). The distance of 6MWT was associated positively with age (P = .042) and inversely with reticulocyte count (P = .42) and interleukin 6 (P = .00). Age modified the effect of interleukin 6 in younger children (P = .038).
Our findings suggest increased baseline levels of biomarkers of hemolysis and inflammation impact on 6MWT performance.
镰状细胞病是全球最常见的遗传性血红蛋白病，会对身体机能产生全身性影响，降低运动能力。
通过6分钟步行试验（6MWT）和生物标志物评估镰状细胞病患儿及青少年的运动能力。
对来自巴西的20名儿童及青少年进行横断面研究。收集人口统计学和社会经济数据。基线测量包括生物标志物（红细胞、血红蛋白、血细胞比容、白细胞、血小板、网织红细胞、乳酸脱氢酶、肌酸磷酸激酶、C反应蛋白、白细胞介素6和胎儿血红蛋白）。在6MWT之前、期间和之后获取以下数据：心率、血压和外周血氧饱和度。
分析了18名5 - 14岁的儿童及青少年，其中61.1%为男孩，100%为黑人或棕色人种，61.1%接受小学教育，家庭收入较低。6MWT的平均步行距离为463.8（137.7）米，显著低于预测值（P <.001）。6MWT的距离与年龄呈正相关（P =.042），与网织红细胞计数呈负相关（P =.42），与白细胞介素6呈负相关（P =.00）。年龄改变了白细胞介素6对年幼儿童的影响（P =.038）。
我们的研究结果表明，溶血和炎症生物标志物的基线水平升高会影响6MWT表现。
