Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena, Modena, Italy.
Medical Physics Unit, Azienda Ospedaliero Universitaria di Modena, Modena, Italy.
Phys Med. 2022 Aug;100:164-175. doi: 10.1016/j.ejmp.2022.06.013. Epub 2022 Jul 25.
Body size is a major determinant of patient's dose during percutaneous coronary interventions (PCI). Body mass index, body surface area (BSA), lean body mass and weight are commonly used estimates for body size. We aim to identify which of these measures and which procedural/clinical characteristics can better predict received dose.
Dose area product (DAP, Gycm), fluoroscopy DAP rate (Gycm/min), fluoroscopy DAP (Gycm), cine-angiography DAP (Gycm), Air Kerma (mGy) were selected as indices of patient radiation dose. Different clinical/procedural variables were analysed in multiple linear regression models with previously mentioned patient radiation dose parameters as end points. The best model for each of them was identified.
Overall 6623 PCI were analysed, median fluoroscopy DAP rate was 35 [IQR 2.7,4.4] Gycm, median total DAP was 62.7 [IQR 38.1,107] Gycm. Among all anthropometric variables, BSA showed the best correlation with all radiation dose parameters considered. Every 1 m increment in BSA added 4.861 Gycm/min (95% CI [4.656, 5.067]) to fluoroscopy DAP rate and 164 Gycm (95% CI [145.3, 182.8]) to total DAP. Height and female sex were significantly associated to a reduction in fluoroscopy DAP rate and total DAP. Coronary angioplasty, diabetes, basal creatinine and the number of treated vessels were associated to higher values.
Main determinants of patient radiation dose are: BSA, female sex, height and number of treated vessels. In an era of increasing PCI complexity and obesity prevalence, these results can help clinicians tailoring X-ray administration to patient's size.
身体大小是经皮冠状动脉介入治疗(PCI)中患者剂量的主要决定因素。体重指数、体表面积(BSA)、瘦体重和体重通常被用作身体大小的估计值。我们旨在确定这些测量值和哪些程序/临床特征可以更好地预测所接受的剂量。
剂量面积乘积(DAP,Gycm)、透视 DAP 率(Gycm/min)、透视 DAP(Gycm)、电影血管造影 DAP(Gycm)、空气比释动能(mGy)被选为患者辐射剂量的指标。不同的临床/程序变量在多个线性回归模型中进行了分析,将上述患者辐射剂量参数作为终点。为每个参数确定了最佳模型。
共分析了 6623 例 PCI,透视 DAP 率中位数为 35 [IQR 2.7,4.4] Gycm,总 DAP 中位数为 62.7 [IQR 38.1,107] Gycm。在所有人体测量变量中,BSA 与所考虑的所有辐射剂量参数显示出最佳相关性。BSA 每增加 1 m,透视 DAP 率增加 4.861 Gycm/min(95%CI [4.656,5.067]),总 DAP 增加 164 Gycm(95%CI [145.3,182.8])。身高和女性性别与透视 DAP 率和总 DAP 的降低显著相关。经皮冠状动脉腔内成形术、糖尿病、基础肌酐和治疗血管数量与较高值相关。
患者辐射剂量的主要决定因素是:BSA、女性性别、身高和治疗血管数量。在 PCI 复杂性和肥胖症患病率不断增加的时代,这些结果可以帮助临床医生根据患者的体型调整 X 射线的使用。