Tippabhatla Abhishek, Atalay Rediet T, Gyftopoulos Alex, Ayele Girma M, Michael Miriam B
Orthopedics, Howard University College of Medicine, Washington, D.C., USA.
Internal Medicine, Howard University College of Medicine, Washington, D.C., USA.
Cureus. 2022 Jun 26;14(6):e26340. doi: 10.7759/cureus.26340. eCollection 2022 Jun.
Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's lymphoma (NHL) and accounts for approximately 25% of all NHLs in developed countries. The patients usually present with constitutional symptoms and rapidly enlarging lymphadenopathy and symptomatic mass typically located in the neck or abdomen, along with an aggressive disease course. Most of the patients present with advanced disease with 60% presenting with stage 3 or 4, and those who present with extranodal involvement are usually seen at an earlier stage. Different conditions are associated with non-Hodgkin's lymphoma ranging from hereditary immunodeficiency disorders, autoimmune disorders, infections such as HIV, Epstein-Barr virus (EBV), hepatitis C virus (HCV), , and drugs such as immunosuppressants and chemotherapeutic agents. Epstein-Barr virus (EBV) is the main etiology of DLBCLs with an identified cause and it accounts for 10% of all DLBCLs. We report a case of a 51-year-old woman who came with a non-traumatic left femur fracture and was subsequently found to have EBV-positive DLBCL. Lymphoma commonly presents as a lymph node swelling and it's uncommon to present as primary bone disease.
弥漫性大B细胞淋巴瘤（DLBCL）是最常见的非霍奇金淋巴瘤（NHL），在发达国家约占所有NHL的25%。患者通常表现为全身症状和迅速增大的淋巴结病，有症状的肿块通常位于颈部或腹部，疾病进展迅速。大多数患者就诊时已处于晚期，60%的患者为3期或4期，而那些出现结外受累的患者通常在较早阶段被发现。多种情况与非霍奇金淋巴瘤相关，包括遗传性免疫缺陷疾病、自身免疫性疾病、感染如HIV、爱泼斯坦-巴尔病毒（EBV）、丙型肝炎病毒（HCV），以及药物如免疫抑制剂和化疗药物。爱泼斯坦-巴尔病毒（EBV）是已明确病因的DLBCL的主要病因，占所有DLBCL的10%。我们报告一例51岁女性病例，该患者因非创伤性左股骨骨折前来就诊，随后被发现患有EBV阳性的DLBCL。淋巴瘤通常表现为淋巴结肿大，以原发性骨病形式出现并不常见。
