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腹主动脉腔内移植物感染。十年经验及文献综述。

Abdominal aortic endograft infection. A decade of experience and literature review.

作者信息

Dominguez-Cainzos Jokin, Rodrigo-Manjon Alejandro, Rodriguez-Chinesta Jose Manuel, Apodaka-Diez Ana, Bonmatí Gonzalo, Bereciartua Elena

机构信息

Servicio de Enfermedades Infecciosas, Hospital Universitario Cruces, Barakaldo, Spain.

Servicio de Enfermedades Infecciosas, Hospital Universitario Cruces, Barakaldo, Spain.

出版信息

Enferm Infecc Microbiol Clin (Engl Ed). 2023 Mar;41(3):155-161. doi: 10.1016/j.eimce.2022.07.002. Epub 2022 Jul 26.

Abstract

INTRODUCTION

Aortic endograft infection is an infrequent but life-threatening complication after endovascular abdominal aortic repair (EVAR). There is no consensus on management of endograft infection and little evidence has been published in our country. Endograft explantation is considered the "gold standar" treatment whereas percutaneous or surgical perigraft and sac drainage associated to antibiotics should be considered and alternative therapy.

METHODS

We carried out a retrospective and descriptive review of abdominal aortic endograft infections at our tertiary center (Hospital Universitario Cruces) during last ten years (2010-2019).

RESULTS

We describe the clinical and microbiological characteristics of 10 EVAR infections, their management and outcomes. The incidence of graft infection after EVAR was 3%. The mean time to the clinical presentation of infection was 16.9 months (median 4.5 months). The microbiological diagnosis was reached in 100% of cases (predominance of gram-positive species). The overall mortality rate was 50% (although the survival rate was 100% after surgical drainage of the sac).

CONCLUSION

Perigraft or aneurysm sac aspiration culture show their diagnostic utility as microbiological diagnosis was reached in all cases despite of blood cultures being only positive in 50% of the samples. Surgical drainage and endograft preservation combined with antibiotherapy show remarkable results. The high heterogeneity in our case series makes difficult to offer general recommendations, thus far, a tailored approach to treatment is suggested.

摘要

引言

主动脉内移植物感染是血管腔内腹主动脉修复术(EVAR)后一种罕见但危及生命的并发症。对于移植物感染的管理尚无共识,我国也鲜有相关证据发表。移植物取出术被认为是“金标准”治疗方法,而经皮或手术进行的移植物周围及瘤腔引流联合抗生素治疗应被视为替代疗法。

方法

我们对过去十年(2010 - 2019年)在我们的三级中心(克鲁塞斯大学医院)发生的腹主动脉内移植物感染进行了回顾性描述性研究。

结果

我们描述了10例EVAR感染的临床和微生物学特征、治疗方法及结果。EVAR术后移植物感染的发生率为3%。感染临床表现出现的平均时间为16.9个月(中位数为4.5个月)。100%的病例达成了微生物学诊断(革兰氏阳性菌为主)。总体死亡率为50%(尽管瘤腔手术引流后的生存率为100%)。

结论

移植物周围或动脉瘤瘤腔穿刺培养显示出其诊断效用,因为尽管血培养仅在50%的样本中呈阳性,但所有病例均达成了微生物学诊断。手术引流和移植物保留联合抗生素治疗显示出显著效果。我们病例系列中的高度异质性使得难以给出一般性建议,因此,建议采用个体化的治疗方法。

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