一名因对奥氮平预致敏而患肺炎的男性的早发型药物超敏反应综合征
Early-Onset Drug Hypersensitivity Syndrome in a Man With Pneumonia Due to Pre-sensitization to Olanzapine.
作者信息
Sogo Azusa, Horiuchi Hiroshi, Ueda Takashi, Miyazaki Hiroshi, Furuya Ryosuke
机构信息
Department of Critical Care and Emergency Medicine, National Hospital Organization Yokohama Medical Center, Yokohama City, JPN.
Department of Dermatology, National Hospital Organization Yokohama Medical Center, Yokohama City, JPN.
出版信息
Cureus. 2022 Jun 27;14(6):e26374. doi: 10.7759/cureus.26374. eCollection 2022 Jun.
Abstract
Drug hypersensitivity syndrome (DHS) generally starts two weeks to two months after administration of certain drugs. Olanzapine has been reported to cause drug reaction with eosinophilia and systemic symptoms (DRESS), but rarely causes drug-induced hypersensitivity syndrome (DIHS). A 49-year-old schizophrenic man was hospitalized for pneumonia and developed DIHS/DRESS 10 days after starting olanzapine. Although reactivation of human herpesvirus 6, which is one of the diagnostic criteria for DIHS, was not confirmed, the diagnostic criteria for DRESS were met. The patient may have developed early-onset DIHS/DRESS because he was sensitized to olanzapine prior to hospitalization.
摘要
药物超敏反应综合征（DHS）通常在使用某些药物后两周至两个月内开始。据报道，奥氮平可引起伴有嗜酸性粒细胞增多和全身症状的药物反应（DRESS），但很少引起药物性超敏反应综合征（DIHS）。一名49岁的精神分裂症男性因肺炎住院，在开始使用奥氮平10天后发生了DIHS/DRESS。虽然未确认人疱疹病毒6的再激活（DIHS的诊断标准之一），但符合DRESS的诊断标准。该患者可能因在住院前对奥氮平致敏而发生了早发性DIHS/DRESS。
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